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Method for extracting cholesterine in lanosterol by supercritical CO2

A technology for lanolin and cholesterol, applied in the field of cholesterol, can solve the problems of low purity and yield of cholesterol, and achieve the effects of reducing chemical consumption, light color and omitting refining steps

Inactive Publication Date: 2007-11-21
XIAMEN KINGDOMWAY VI TAMIN INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Liang Bing (Liang Bing. Journal of Shenyang Institute of Chemical Technology, 2001 (15): 16) reported extraction and separation of lanolin with supercritical carbon dioxide fluid, but the purity and yield of cholesterol obtained were not high

Method used

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  • Method for extracting cholesterine in lanosterol by supercritical CO2

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Experimental program
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Effect test

Embodiment 1

[0028] Referring to Fig. 1, put 100g of lanolin alcohol into 1L extractor 1 after heating and melting, add 30ml of ethanol, seal the extractor, open the gas valve of the carbon dioxide steel cylinder, and make the carbon dioxide pressure reach 35Mpa through circulating cooler 4 and high-pressure pump 3. The critical carbon dioxide is preheated to 45°C by the preheater 2, enters the extractor 1, and extracts for 120 minutes. After the pressure is released and reduced by the pressure regulating valve 6, 78.0 g of lanolin alcohol is obtained in the separation kettle 5, and the extraction residue is obtained in the extractor. After dissolving with 70ml of ethanol, 17.5g of cholesterol was obtained after cooling down and crystallizing, with a cholesterol content of 95.2%.

Embodiment 2

[0030] Similar to Example 1, heat and melt 80g of lanolin alcohol into a 1L extractor, add 35ml of water, seal the extractor, open the gas valve of the carbon dioxide steel cylinder, and make the carbon dioxide pressure reach 35Mpa through a circulating cooler and a high-pressure pump, supercritical Carbon dioxide is preheated to 50°C by the preheater and enters the extractor. After 300 minutes of extraction, the pressure regulating valve is released to reduce pressure, and 60.3g of lanolin alcohol is obtained in the separation kettle. The extraction residue obtained in the extractor is dissolved in 60ml of ethanol and then cooled. After crystallization, 12.0 g of cholesterol was obtained, with a cholesterol content of 93.7%.

Embodiment 3

[0032] Similar to Example 1, heat and melt 80g of lanolin alcohol and put it into a 1L extractor, add 35ml of acetone, seal the extractor, open the gas valve of the carbon dioxide steel cylinder, and make the carbon dioxide pressure reach 25Mpa through a circulating cooler and a high-pressure pump, supercritical Carbon dioxide is preheated to 50°C by the preheater and enters the extractor. After extraction for 120 minutes, the pressure regulating valve is released to reduce the pressure, and 63.6g of lanolin alcohol is obtained in the separation kettle. The extraction residue obtained in the extractor is dissolved in 80ml of ethanol and then cooled. After crystallization, 13.04 g of cholesterol was obtained, with a cholesterol content of 94.2%.

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Abstract

A method for extracting cholesterol from lanosterol by supercritical CO2 is carried out by putting lanosterol and laminating agent into extractor, delivering CO2 into extractor by compressing pump, adjusting CO2 extractor pressure and temperature, controlling CO2 flow speed, extracting to obtain CO2 with solute, decompressing CO2 with solute, separating to obtain cholesterol and lanosterol, dissolving for cholesterol by solvent, lowering temperature and crystallizing to obtain high-content final product. It's simple and inodorous, has better purity and light color.

Description

technical field [0001] The invention relates to cholesterol, in particular to a method for extracting and separating cholesterol from lanolin by supercritical carbon dioxide. Background technique [0002] Cholesterol is the main raw material for the production of vitamin D3, steroid hormones and artificial bezoar. It is also a high-quality raw material for the manufacture of liquid crystals. It can also be used as an additive for aquatic feed and cosmetics. [0003] Lanolin is a saponification product of lanolin. Lanolin is the secretion of the sebaceous glands of sheep. It is a multi-component mixture of esters and can be recovered from wool washing wastewater. According to statistics, about 250,000 tons of lanolin are extracted from wool washing wastewater in my country every year, and there are abundant lanolin sources. [0004] Crude lanolin is a brown, foul-smelling sticky substance. Lanolin is mainly an ester formed by higher molecular weight fatty acids (C7-C41) an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00C07J75/00
CPCY02P20/54
Inventor 李专成李丹杨景祥
Owner XIAMEN KINGDOMWAY VI TAMIN INC
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