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Combination including isoglycyrrhizinate and oxymatrine and the purpose thereof

A technology of isoglycyrrhizic acid and its composition, applied in the field of medicine, can solve the problems of malabsorption, low bioavailability, poor clinical curative effect, poor absorption and side effects of oral preparations of glycyrrhizic acid, etc.

Active Publication Date: 2007-10-31
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the steroid-like effect of glycyrrhizic acid, there are serious adverse reactions such as water and sodium retention, high blood pressure and hypokalemia after long-term administration, and oral administration is easy to form micelles in the intestinal tract, resulting in malabsorption and low bioavailability
The clinical efficacy of matrine drugs is not good, and they have been used for the treatment of hepatitis B for a long time, and have gastrointestinal irritation
There are clinical reports that the combined application of diammonium glycyrrhizinate capsules and matrine injection has achieved good curative effect in the treatment of chronic hepatitis B, but this method has not completely solved the problem of poor absorption of oral preparations of glycyrrhizinate, excessive side effects, and excessive dosage of combined drugs. The problem of inconvenient use for large patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Magnesium isoglycyrrhizinate and matrine in different proportions on CCL 4 Protective effect of induced liver injury in mice

[0021] Experimental animals: Kunming mice, male. Provided by the Experimental Animal Center of China Pharmaceutical University, animal certificate number: Su Dong (Quality) 200501002

[0022] Experimental drugs: matrine, magnesium isoglycyrrhizinate. Provided by the Chinese Medicine Laboratory of the R&D Center of Jiangsu Zhengda Tianqing Pharmaceutical Co., Ltd., batch number: 051002. According to the requirements of the experiment, the solutions with different proportions of concentration were prepared with physiological saline.

[0023] 70 Kunming mice of 18-20g, male, were randomly divided into 7 groups according to body weight: normal control group, model control group, 3 groups of matrine and magnesium isoglycyrrhizinate composition group with different ratios, matrine group, magnesium isoglycyrrhizinate group. According to d...

Embodiment 2

[0027] Example 2 The protective effect of the composition of magnesium isoglycyrrhizinate and matrine in different ratios on immune liver injury in mice induced by BCG+LPS.

[0028] Experimental animals: Kunming mice, male. Provided by the Experimental Animal Center of China Pharmaceutical University, animal certificate number: Su Dong (Quality) 200501002

[0029] Experimental drugs: magnesium isoglycyrrhizinate and matrine were provided by the Chinese Medicine Laboratory of the R&D Center of Jiangsu Zhengda Tianqing Pharmaceutical Co., Ltd., batch number: 051002. According to the requirements of the experiment, physiological saline was used to make solutions with different proportion concentrations for injection administration. Bacillus Calmette-Guerin (BCG): Shanghai Institute of Biological Products, batch number: 200504001. Lipopolysaccharide (LPS): product of Sigma, USA. AST and ALT kits: Nanjing Jiancheng Institute of Bioengineering, batch number: 20050905, 20050828. ...

Embodiment 3

[0035] Embodiment 3 acute toxicity test

[0036] Experimental animals: Kunming mice, male. Provided by the Experimental Animal Center of China Pharmaceutical University, animal certificate number: Su Dong (Quality) 200501002.

[0037] Experimental drugs: magnesium isoglycyrrhizinate, matrine. Provided by the Chinese Medicine Laboratory of the R&D Center of Jiangsu Zhengda Tianqing Pharmaceutical Co., Ltd., batch number: 051002.

[0038] Test according to the requirements of acute toxicity test. The LD of the following groups of experimental drugs were obtained respectively 50 value,

[0039] group

Method of administration

LD 50 (mg / kg)

95% confidence interval (mg / kg)

Magnesium isoglycyrrhizinate

matrine

Bitter: different sweet (2.5:1)

Bitter: different sweet (10:1)

Bitter: different sweet (1:2.5)

Bitter: different sweet (1:10)

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Abstract

The invention provides a medicinal composition which comprises kurarinone or its derivatives and isoglycyrrhizinic acid or its derivatives. The invention also provides the use of the pharmaceutical composition in treating acute and chronic hepatitis and related diseases. the invention also provides various dosage forms of the pharmaceutical composition.

Description

technical field [0001] The invention belongs to the field of medicine. It relates to a pharmaceutical composition and its use. The pharmaceutical composition contains isoglycyrrhizic acid and matrine or their derivatives. And the application of the pharmaceutical composition in preventing and treating human hepatitis or hepatitis-related diseases or tumors. Background technique [0002] Liver disease, especially viral hepatitis, is a common and frequently-occurring disease in my country. At present, there is no drug with ideal therapeutic effect on it. Clinically, antiviral drugs are often used for treatment, and liver-protecting drugs are added to improve the curative effect. However, due to the inaccurate therapeutic effect and strong clinical side effects of such drugs, the prognosis is often unsatisfactory. [0003] Both glycyrrhizic acid and matrine have certain anti-hepatitis virus and liver protection effects, and similar products of the two have been used in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P1/16A61P31/20A61P31/14A61K31/4375
Inventor 沈军耿文军于飞
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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