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Ginger oil for killing schistosoma japonicum cercariae

A technology of schistosomiasis cercariae and ginger oil, which is applied in the field of articles for killing schistosomiasis, can solve problems such as difficult to popularize and use, skin irritation, discomfort, etc., and achieve the effect of convenient cleaning, small skin irritation and good effect

Inactive Publication Date: 2007-09-19
YANGTZE UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although various protective agents made of these drugs have a strong effect of killing cercariae, the cost is relatively high, and the ointment, paste, and oil-based protective agents made of these drugs are relatively viscous, and it is difficult to apply them on the skin. Very thick, not only uncomfortable, but also irritating to the skin and easy to fall off
Therefore, it is difficult to promote the use of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1, the test of killing the cercariae of Schistosoma japonicum.

[0015] Take 100 microliters of ginger oil and place it on a glass slide, add 100 living Schistosoma japonicum cercariae to each piece, make 5 slices each time, and do 2 times in total. The active ones were judged as dead, and the time to kill the cercariae was defined as the death of all cercariae. A dechlorinated clear water control group is also set up, and its control group is: tap water is exposed to sunlight under sunlight, and after the chlorine contained in the water is allowed to evaporate, it becomes dechlorinated clear water. Take 100 microliters of dechlorinated water and put it on a glass slide, add 100 live Schistosoma japonicum cercariae to each slide, make 5 slices each time, and do 2 times in total. The time for ginger oil to kill Schistosoma japonicum cercariae is shown in the table below:

[0016]

[0017]

[0018] The results of its ginger oil killing the ce...

Embodiment 2

[0019] Embodiment 2: Animal infection test.

[0020] For the first time, 10 mice were used for the experiment, and the abdomen of each mouse was shaved. The range of shaved hair was 2 cm × 3 cm, and 0.1 ml of 10% chloral hydrate was injected subcutaneously for anesthesia, and ginger oil was taken each time. Put 100 microliters on each glass slide, put 40 cercariae of Schistosoma japonicum on each glass slide, stick it on the abdomen of anesthetized mouse after 30 minutes, infect 10 mice for 20 minutes, dissect them after 40 days, and use The worms were collected by perfusion and shredding. Firstly, the superior vena cava was perfused and washed, and the number of adults of Schistosoma japonicum in the liver and intestinal venous plexus was counted under a dissecting microscope. The liver and mesentery were crushed for inspection, the number of unwashed adult Schistosoma japonicum was counted, and the infection rate was calculated. A control group was set up for infection with ...

Embodiment 3

[0024] Embodiment 3: apply ginger oil on human feet, hands, and arms, and then go into the water to work, which can prevent the cercariae of Schistosoma japonicum from penetrating into the skin, and can prevent Schistosoma japonicum infection.

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PUM

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Abstract

Zingiber officinale oil can kill cercariae of Schistosoma japonicum, and is extracted from Zingiber officinale. The invention discloses a drug capable of killing cercariae of Schistosoma japonicum. Zingiber officinale oil can be made into emulsions, creams, water agents, or oils, which prevent cercariae from thrusting human body and infection with schistosoma japonicum. Because of being a botanical preparation, Zingiber officinale oil has the advantages of less skin irritation, no side effects, safety and reliability, rich resourses, and low cost.

Description

Technical field: [0001] The invention relates to articles for killing schistosomes, in particular to killing cercariae of Schistosoma japonicum with ginger oil. Background technique: [0002] Schistosomiasis is a disease that seriously endangers the health and life safety of the people. The population of my country's current schistosomiasis endemic areas reaches 60 million people, and the heavily infected areas are mainly Jianghan Plain, Dongting Lake area, Poyang Lake area, and river (lake, continent) beach areas along the Yangtze River. According to statistics in 1984, the number of schistosomiasis patients in the country reached 843,000. In recent years, schistosomiasis patients have had a serious upward trend. The country will invest a lot of manpower, material resources and financial resources for free treatment of schistosomiasis patients every year. If the feces of schistosomiasis patients flow into the water, the schistosomiasis eggs will hatch into miracidia in the...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/06A61K9/107A61K9/00A61P33/12A61K125/00
CPCY02A50/30
Inventor 边藏丽袁岳沙张万明丁建中夏鹏程松
Owner YANGTZE UNIVERSITY
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