Compound nicotinamide medicine for antiphlogosis, wet storage and eliminating spot

Abstract

The compound nicotinamide medicine for antiphlogosis, wet storage and eliminating spot consists of nicotinamide 2-10 wt%, trans- or cis-vitamin A acid 0.025-0.05 wt%, and corticosteroid 0.025-1 wt%. It has functions of moistening skin, diminishing inflammation, inhibiting melanogenesis, and treating eczema, skin pruritus, acne, etc.

Description

technical field [0001] The invention relates to a compound skin external pharmaceutical composition of niacinamide, in particular to a compound niacinamide pharmaceutical composition with the characteristics of anti-inflammation, moisturizing and moisturizing, reducing skin pigmentation and anti-aging skin. Background technique [0002] Nicotinamide is an antioxidant that can effectively prevent cells and cell membranes from free radical damage, and can eliminate superoxide anion free radicals that play a role in inflammation; it also has anti-inflammatory activity, can inhibit phosphodiesterase and / or inhibit Mast cell degranulation can directly inhibit the release of histamine receptors and histamine, inhibit the chemotaxis of neutrophils, and inhibit the transformation of lymphocytes and the regulation of genes. [0003] It has been confirmed in keratinocyte culture that nicotinamide can increase the synthesis of ceramide, fatty acid and cholesterol, and has the effect of...

AI Technical Summary

Problems solved by technology

[0004] However, many diseases of the skin, such as eczema and dry skin diseases, are closely related to the loss of the integrity of the lipid barrier function of the stratum corneum. In addition, other causes cause a variety of acute and chronic syndromes, so the therapeutic effect of a single drug is often not ideal.