Medicine for preventing and treating cardiovascular and cerebrovascular diseases by increasing hypoxia-resistant ability and its preparing method

A technology for cardiovascular and cerebrovascular diseases and hypoxia resistance, applied in cardiovascular system diseases, medical preparations containing active ingredients, anti-toxins, etc., can solve problems such as low bioavailability, no obvious synergy, gastrointestinal discomfort, etc. Achieve high bioavailability, obvious curative effect, and increase the effect of myocardial blood oxygen supply

Inactive Publication Date: 2007-08-15
SHANDONG XINXIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, ginkgo biloba preparations have been widely used in the pharmaceutical industry and health care products industry. However, the current single-ingredient preparations that use ginkgo biloba as raw materials have the disadvantages of gastrointestinal discomfort, low absorption rate, and slow effectiveness.
In the prior art, the preparations of two or three components are used to treat cardiovascular and cerebrovascular diseases, such as the compound ginkgo capsule disclosed in application number 02138757.5, although considering the balance of organs such as the human heart, lung, liver, stomach, and spleen, it reduces the Gastrointestinal discomfort, but its bioavailability is still low, compared with the single-component ginkgo biloba preparation, there is no obvious synergistic effect in improving the hypoxia tolerance of cells
Application No. 02134085.4 discloses a drug for the treatment of cardiovascular and cerebrovascular diseases and sequelae of stroke, which reduces gastrointestinal discomfort compared with single preparations, but has the disadvantages of long course of treatment and slow onset of effect

Method used

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  • Medicine for preventing and treating cardiovascular and cerebrovascular diseases by increasing hypoxia-resistant ability and its preparing method
  • Medicine for preventing and treating cardiovascular and cerebrovascular diseases by increasing hypoxia-resistant ability and its preparing method
  • Medicine for preventing and treating cardiovascular and cerebrovascular diseases by increasing hypoxia-resistant ability and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Weigh 800g of ginkgo leaves and 50g of American ginseng, weigh the processed ginkgo leaves and American ginseng according to the prescription, put them in a frying pan, add 8 to 10 times of water for the first time, heat and decoct for 2 hours, and filter; add water to the filter residue for the second time 4 to 6 times, heat and decoct for 2 hours, filter; add water to the filter residue for the third time 2 to 3 times, heat and decoct for 1.5 hours, filter, combine three decoction liquids, after standing for 24 hours, filter to remove insoluble matter, filtrate for concentration. Concentrate the above-mentioned filtrate to a relative density of 1.25 (the concentration pressure is 0.05mpa, the temperature is 60°C, and the time is 12 hours), the amount of the filtrate is concentrated to 1 / 3-1 / 4, and the prepared clear paste is put into a drying tray, Thickness not exceeding 1.0cm, placed in an oven at a temperature of 75-80°C for 4 hours, turned over the dried material ...

Embodiment 2

[0016] Weigh 600 g of ginkgo biloba leaves, 70 g of American ginseng, 15 g of taurine, 5 g of tea polyphenols, 2 g of ferrous gluconate, and 0.01 g of folic acid. The preparation method is the same as in Example 1.

Embodiment 3

[0018] Weigh 900 g of ginkgo leaves, 40 g of American ginseng, 5 g of taurine, 15 g of tea polyphenols, 6 g of ferrous gluconate, and 0.05 g of folic acid. The preparation method is the same as in Example 1.

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Abstract

The invention discloses a preparation for improving tolerance to anoxia and preventing and treating cardio-cerebrovascular disease and its preparation method. The preparation is prepared from (by weight part) ginkgo leaf 600-900, american ginseng 40, taurine 5-15, tea polyphenol 5-15, ferrous gluconate 2-6, and folic acid 0.01-0.05 by dectocting ginkgo leaf and american ginseng, filtrating, concentrating, drying, pulverizing taurine, tea polyphenol, ferrous gluconate, and folic acid respectively, mixing, and drying. Compared with present unilateralism or compound preparation, the inventive preparation has remarkable effects in improving cellulate tolerance to anoxia, preventing and treating cardio-cerebrovascular disease, reducing blood pressure and lipid with rapid action, high bioavailability, no subsidiary reaction; and it can be used for long term administration.

Description

technical field [0001] The invention relates to a preparation and a preparation method thereof, in particular to a preparation and a preparation method for improving hypoxia resistance to prevent and treat cardiovascular and cerebrovascular diseases. Background technique [0002] The main components of Ginkgo biloba are ginkgo flavonoids and diterpene lactones. Others also contain phenols, acids, polyprenyl alcohol, steroids, sugars and trace elements. Prevent and treat cardiovascular and cerebrovascular diseases, promote blood vessel expansion, increase blood flow, antagonize platelet activating factor, resist lipid peroxidation, resist ultraviolet rays, resist brain damage, improve senile learning and memory impairment, enhance body immunity, and prolong the absence of mice. The average survival time of oxygen, enhance the body's tolerance to hypoxia, reduce serum triglycerides, cholesterol and many other effects. Therefore, ginkgo biloba preparations have been widely use...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P9/10A61P39/00A61K31/185A61K31/191A61K31/353A61K31/519
Inventor 张杰张俊多朗
Owner SHANDONG XINXIAN PHARMA
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