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Method of preparing aminoglucose composite sulphate

A technology of glucosamine sulfate and glucosamine sulfate, applied in the direction of amino sugar, etc., can solve the problems of high cost, complicated operation, and difficulty in industrialization, and achieve the effect of low cost, simple process, and good stability

Inactive Publication Date: 2007-08-08
庄建华 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] But this operation is very complicated, the cost is also high, and it is difficult to realize industrialization

Method used

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  • Method of preparing aminoglucose composite sulphate
  • Method of preparing aminoglucose composite sulphate
  • Method of preparing aminoglucose composite sulphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 22 g of glucosamine hydrochloride was dissolved with 300 ml of water by stirring, and the pH value of the reaction solution was adjusted to 8.0 with NaOH aqueous solution at room temperature. Then the pH value of the reaction solution was adjusted to 4.8 with dilute sulfuric acid and stirred for a while, then concentrated under vacuum until crystals were precipitated, cooled to crystallize, filtered, and dried to obtain 27.8 g of glucosamine sulfate sodium chloride compound salt.

Embodiment 2

[0034] Glucosamine hydrochloride 32g and 400ml 50% ethanol aqueous solution were stirred and dissolved, at room temperature, with NaOCH 2 CH 3 Solution Adjust the pH value of the reaction solution to 8.1. Then the pH value of the reaction solution was adjusted to 4.6 with dilute sulfuric acid and stirred for a while, then concentrated under vacuum until crystals were precipitated, cooled to crystallize, filtered, and dried to obtain 37.5 g of glucosamine sulfate sodium chloride compound salt.

Embodiment 3

[0036] Glucosamine hydrochloride 15g and 200ml water were stirred and dissolved, at room temperature, with Na 2 CO 3 An aqueous solution was used to adjust the pH value of the reaction solution to 8.0. Then the pH value of the reaction solution was adjusted to 4.5 with dilute sulfuric acid and stirred for a while, then concentrated under vacuum until crystals were precipitated, cooled to crystallize, filtered, and dried to obtain 19 g of glucosamine sulfate sodium chloride compound salt.

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Abstract

The invention discloses a making method of composite salt of aminoglucose sulfate, which comprises the following steps: transmitting amino glucose hydrochlorate into amino glucose in the alkaline solution; generating chloride simultaneously; acting sulfuric acid and amino glucose to form aminoglucose sulfate; condensing; crystallizing; obtaining the product.

Description

technical field [0001] The invention relates to a preparation method of medicine, in particular to a preparation method of glucosamine sulfate compound salt. Background technique [0002] Glucosamine sulfate sodium chloride compound salt (potassium salt) was first recorded in the 27th edition of the United States Pharmacopoeia. It is a drug for treating joint diseases. Its chemical name is: glucosamine sulfate sodium chloride compound salt or glucosamine sulfate chloride Potassium compound salts, their specific structural formulas are shown in the figure below. [0003] [0004] Glucosamine sulfate potassium salt Glucosamine sulfate sodium salt [0005] (Compound Salt) (Compound Salt) [0006] The existing general and commonly used preparation method is to dechlorinate the aqueous solution of glucosamine hydrochloride through anion conversion resin, and the free aqueous solution of glucosamine produced reacts with sulfuric acid to form glucosamine sulfate, then adds...

Claims

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Application Information

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IPC IPC(8): C07H5/06
Inventor 庄建华庄小恩
Owner 庄建华
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