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Method of extracting coumarin by supercritical carbon dioxide

A carbon dioxide and supercritical technology, applied in organic chemistry, pharmaceutical formulation, bulk chemical production, etc., can solve problems such as complex operation, adverse effects, and solvent residue, and achieve low operating temperature, no organic solvent residue, and less pollution. Effect

Inactive Publication Date: 2007-08-08
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] In order to overcome a series of problems such as low efficiency, complex operation, solvent residues, and adverse effects on the human body that exist in the method for extracting capillary coumarin components with organic solvents such as chloroform, acid, and alkali solutions, the applicant has adopted super Process flow of critical carbon dioxide extraction of coumarin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Firstly, 0.5kg capillary herb was roughly treated, and put into the extraction kettle of a 5L supercritical extraction device, using supercritical carbon dioxide as the extraction solvent, the extraction pressure was 10MPa, the temperature was 30°C, and the extraction time was 0.5 hours. During the extraction process, the temperature of the separation kettle was 30°C for decompression analysis and separation, and the crude extract of capillary coumarins was collected, and 1.60 g of its extract was obtained after drying. The sample yield was 0.32%. The content of bean element is 41.60%.

Embodiment 2

[0026] Firstly, 0.5 kg of capillary herb was roughly treated and put into the extraction kettle of a 5L supercritical extraction device, using supercritical carbon dioxide as the extraction solvent, the extraction pressure was 25MPa, the temperature was 40°C, and the extraction time was 1 hour. During the extraction process, the temperature of the separation tank was 15°C for decompression analysis and separation, and the extract of capillary coumarin was collected and dried to obtain 12.05g of the extract, with a sample yield of 2.41%. The 6,7-dimethoxycoumarin in the sample The element content is 38.30%.

Embodiment 3

[0028] Firstly, 0.5kg of capillary herb was roughly treated, put into the extraction kettle of a 5L supercritical extraction device, and supercritical carbon dioxide was used as the extraction solvent, the extraction pressure was 60MPa, the temperature was 60°C, and the extraction time was 3 hours. During the extraction process, the temperature of the separation tank was 45°C for decompression analysis and separation, and the extract of caperifera coumarin was collected, concentrated and dried under reduced pressure to obtain 13.55g of the extract, the sample yield was 2.71%, and the 6,7-dimethoxy The content of base coumarin is 35.41%.

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Abstract

The invention discloses an extracting method of coumarins from traditional Chinese medicine through hypercritical carbon oxide technique, which comprises the following steps: processing capillary Artemisia drug; placing in the extracting autoclave based on hypercritical carbon oxide as extracting solvent; extracting at 30-60 deg.c under 10-60Mpa for 0.5-3h; decompressing to separate in the separating autoclave at 15-45 deg.c; collecting the extract of capillary Artemisia coumarins.

Description

technical field [0001] The invention belongs to the technical field of extraction of active ingredients in traditional Chinese medicine, and in particular relates to the technical field of extracting coumarin, an active ingredient in capillary wormwood, by using supercritical carbon dioxide technology. Background technique [0002] Yinchen: bitter, slightly cold, returns to the spleen, stomach, liver, gallbladder meridian, clears damp and heat, benefits the liver and gallbladder, "The Classic" "mainly rheumatism, cold and heat evil, heat-induced jaundice". It has significant choleretic and liver protection effects, and is widely used in various hepatitis, especially icteric hepatitis. Acid, etc. are its main choleretic and liver-protecting active ingredients. [0003] 6,7-dimethoxycoumarin also has the effect of lowering fat and beautifying skin. For example, it is recorded in Materia Medica that "Yin Chen long-term clothing lightens the body, nourishes Qi and resists agin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/16A61K36/28
CPCY02P20/54
Inventor 肖小河金城周旭
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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