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Dissolution determination method of hawthorn extract lipid-lowering dispersion tablet

A determination method and technology for dispersible tablets, which are applied in the directions of measuring devices, analytical materials, testing pharmaceutical preparations, etc., can solve the problems of insoluble, unreliable, and low content, and achieve the effect of strong specificity and strong feasibility.

Active Publication Date: 2007-08-01
宁夏启元国药有限公司
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Problems solved by technology

But because the content of active ingredients or index ingredients (flavonoids and triterpene acids, wherein triterpene acids are mainly ursolic acid and oleanolic acid etc.) in the Hawthorn Extract Jiangzhi Dispersible Tablets is very low, and among them The flavonoids are insoluble in water, 0.5% sodium lauryl sulfate solution, dilute hydrochloric acid and buffer solution, therefore, cannot be determined by conventional dissolution methods, and thus cannot be reliably used to predict the bioavailability of drugs

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  • Dissolution determination method of hawthorn extract lipid-lowering dispersion tablet

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Embodiment Construction

[0008] Get Hawthorn Essence Jiangzhi Dispersible Tablets, according to dissolution assay (Chinese Pharmacopoeia version in 2005 two appendix XC second method), with isopropanol-water (2: 3) 1000ml as dissolution medium, rotating speed is 100 revolutions per minute, Operate according to the law, after 30 minutes, get the solution 10ml, filter, get the subsequent filtrate as the test solution, measure the absorbance respectively at the wavelength of 278nm according to the spectrophotometry method; in addition, take 10 hawthorn essence lipid-lowering dispersible tablets, Grind finely, accurately weigh an appropriate amount (equivalent to the average tablet weight), put it in a 1000ml measuring bottle, add 200ml of the above-mentioned dissolution medium, ultrasonicate for 60 minutes (power 160W, frequency 40KHz), take it out, let it cool, and dilute it with the above-mentioned dissolution medium to scale, shake well, filter, take the subsequent filtrate as the control solution, mea...

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Abstract

This invention relates to haw bezafibrate discrete slice fuse concentration test method, which considers chromocor compound in ultraviolet area, wherein, the slices bezafibrate compound is of large volume and the alcohol isopropylicum-water the main component is as triterpene acids and chromocor compound of good solution property to establish the fuse concentration method by lighting ultraviolet method.

Description

technical field [0001] The invention relates to a quality control method of Hawthorn Essence Jiangzhi Dispersible Tablets, in particular to a method for measuring the dissolution rate of Hawthorn Essence Jiangzhi Dispersible Tablets. Background technique [0002] Dissolution determination of oral solid dosage forms is an important measure to predict the bioavailability of drugs. The conventional method for measuring the dissolution rate is to use water, 0.5% sodium lauryl sulfate solution, dilute hydrochloric acid or buffer solution as the dissolution medium. But because the content of active ingredients or index ingredients (flavonoids and triterpene acids, wherein triterpene acids are mainly ursolic acid and oleanolic acid etc.) in the Hawthorn Extract Jiangzhi Dispersible Tablets is very low, and among them The flavonoids are insoluble in water, 0.5% sodium lauryl sulfate solution, dilute hydrochloric acid and buffer solution, therefore, cannot be determined by conventio...

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Application Information

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IPC IPC(8): G01N21/33G01N21/17G01N33/15
Inventor 丁建宝格日勒亓伟田文荣
Owner 宁夏启元国药有限公司
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