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Dripping pills for clearing heat and expelling-coagulates, and its preparing method

A technology for clearing away heat and dissipating stagnation and dropping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve problems such as low bioavailability, unstable quality, and long disintegration time limit, and achieve bioavailability High drug stability, good drug stability, and beneficial to GMP management

Inactive Publication Date: 2007-07-25
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional preparation technology, such oral preparations have long disintegration time, poor absorption, slow onset, and low bioavailability, which affect the full play of drug efficacy.
At the same time, it is easy to split, change color, absorb moisture, etc. during storage, and the quality is unstable

Method used

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  • Dripping pills for clearing heat and expelling-coagulates, and its preparing method
  • Dripping pills for clearing heat and expelling-coagulates, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Take Senecio 3000g, add water to decoct twice, add 8 times the amount of water for the first time, and 6 times the amount for the second time, decoct for 2 hours each time, combine the decoction, let stand for 12 hours, filter , the filtrate is concentrated into an extract with a relative density of 1.12 to 1.22 (60°C), adding ethanol to make the alcohol content 60%, stirring evenly, standing for 12 hours, filtering, reclaiming ethanol from the filtrate, and concentrating to a relative density of 1.15 to 1. 25 (60°C) extract, add ethanol to make the alcohol content 70%, stir evenly, let stand for 24 hours, take the supernatant to recover ethanol, concentrate to extract, and vacuum dry the extract to obtain the extract. Take the extract, crush it, and pass through a 100-mesh sieve. Senecio extract by weight ratio: polyethylene glycol 6000 =1:2 ratio, add to the melted matrix (85°C), stir evenly, drop into simethicone coolant (4°C), separate drop pills, absorb...

Embodiment 2

[0017] Embodiment two: get the extract of embodiment one, pulverize, cross 100 mesh sieves. Senecio extract by weight ratio: mixed matrix = 1: 1.5 (polyethylene glycol 6000: poloxamer according to 1: 0.3 formula), add to the melted mixed matrix (85 ° C), stir well , drop into simethicone coolant (4°C), separate the dropping pills, absorb the coolant, and dry to obtain.

Embodiment 3

[0018] Example 3: In this example, through Senecio extract and different matrix formulations, the roundness, pill weight difference, hardness, dissolution time and other indicators are investigated to determine the weight ratio of the extract to a single or mixed matrix.

[0019] Senecio extract and different matrix formulation tests (extracts are 1 part)

[0020] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the temperature of the drug material insulation and dripper is 85-90°C; the dripping speed is 30-50 capsules / min.

[0021] 2. The above results show that all the indicators of No. 4~11 experiments are good, that is, when the ratio of the extract to the matrix is ​​1:1~1:5, it can be dripped smoothly. However, considering the dosage and other factors, the preferred ratio is Test No. 4, 6, 8, and 10, that is, the ratio of extract to matrix is ​​1:1-1:2.

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PUM

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Abstract

A dripping pill of senecio for treating acute conjunctitis, acute pharyngolaryngitis, acute tonsillitis, acute enteritis, acute bacterial dycentery, upper respiratory tract inflammation, etc is prepared from senecio. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a heat-clearing and sanjie dropping pill and a preparation process thereof. Background technique [0002] Senecio is the dry aerial part of Senecio scandens Buch, -Ham. Growing on hillsides, under sparse forests, forest edges, roadsides, and ditch grass. Mainly produced in Jiangsu, Zhejiang, Guangxi and Sichuan. Senecio, formerly known as Qianliji, was first recorded in "Supplements to Materia Medica", and has the functions of anti-inflammatory and detoxification, dispelling stagnation and relieving pain. Folks are used to treat boils, carbuncles, cellulitis, erysipelas and other acute infections; various acute inflammations, bacillary dysentery, toxemia, sepsis, Pseudomonas aeruginosa infection; acute subacute conjunctivitis, etc. Modern chemical composition studies have shown that it contains active substances such as butteraxanthin,...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/20A61K9/02A61P11/04A61P27/02A61P27/16A61P17/00A61P1/12
Inventor 陈茜滕慧丽
Owner 陈茜
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