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Percutaneous adhering preparation of hydrochloride nefopam

A technology of nefopam hydrochloride and transdermal patch, applied in the field of transdermal patch preparation, can solve the problems of restricting the area of ​​the transdermal preparation, the transdermal rate cannot meet the treatment requirements, etc.

Inactive Publication Date: 2007-07-25
陶燃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The dosage of the transdermal drug delivery system is determined by the effective release area and the transdermal rate of the drug. Due to the physical and chemical properties of most drugs, the transdermal rate cannot meet the treatment requirements, and the practical application restricts the transdermal preparation. the area of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1, preparation contains the transdermal patch tablet of Nefopam hydrochloride. The method comprises the steps of dissolving medicine in water, adding auxiliary materials, stirring to form a gel, and then packaging to prepare a gel-like transdermal patch.

Embodiment 2

[0013] Embodiment 2, using the gel transdermal patch during the treatment process using the ultrasonic conductivity meter. Put the patch prepared in Example 1 into the corresponding placement position of the treatment head, and press it firmly. Remove the anti-adhesive paper on the concave surface of the patch, stick the patch together with the treatment head to the skin of the treatment area, and remove it after the treatment is over.

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PUM

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Abstract

A transdermal paster of nefopam hydrochloride for treating the cancerous pain of later-phase cancer and dropping drug is prepared from nefopam and assistants. It can be used for the ultrasonic-type, ion leading-in type, electric perforating type, or high-pressure gas type medicine supplying system.

Description

Technical field [0001] The invention relates to a transdermal patch preparation of non-narcotic analgesic-Nefopam hydrochloride. Further, the patent of the present invention relates to administering drugs with a low-frequency ultrasonic drug delivery system to exert an analgesic effect on cancer and to treat drug addiction. Background technique [0002] Advanced cancer pain is a social problem. For example, long-term use of morphine drugs can easily lead to addiction. In my country, 1 million cancer patients suffer from pain every day. On the other hand, drug addiction is also a major social problem, and effective drugs need to be provided for treatment [0003] Nefopam hydrochloride, also known as Pingtongxin, Meboxazine, and Jishuping. Properties are white crystalline powder, odorless, bitter taste. Soluble in water, chloroform and methanol. Action and use: It is a non-narcotic analgesic, its mechanism of action is not yet clear, it does not belong to the opioid recept...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/00A61K31/553A61P25/04
Inventor 陶燃
Owner 陶燃
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