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Preparation method for traditional Chinese medicine for gastric motility

A technology of gastric motility and traditional Chinese medicine, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as obvious side effects of morphine, and achieves alleviation of gastric motility disorders, low price, and small dosage. Effect

Active Publication Date: 2009-08-26
GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the side effects of morphine are also obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1 - preparation of Muxiangweitai dripping pills

[0050] Prescription: Muxiang Weitai 100

[0051] PEG6000 300~500

[0052] Operation: Melt the prescribed amount of matrix on a water bath at 85°C, add Muxiangweitai under stirring, mix well, keep warm at 85°C for 10-20 minutes, and drop to 5-5 with a dripping machine with an inner diameter of 1.8mm In the condensing agent at 15°C, take out the dropping pills, shake off the condensing agent, and granulate. Each dropping pill weighs 30-50 mg, contains 7.5 mg of Muxiang Weitai, which is equivalent to 0.25 g of Muxiang crude drug, and has a yield of 85-98%.

Embodiment 2

[0053] Example 2 - Preparation of Muxiangweitai Dispersible Tablets

[0054] Prescription: Muxiangweitai-β-cyclodextrin inclusion complex 30

[0055] Low-substituted hydroxypropyl cellulose 10~20

[0056] Starch 35~45

[0057] Crospovidone XL—10 5~15

[0058] Operation: Muxiangweitai-β-cyclodextrin inclusion compound, low-substituted hydroxypropyl cellulose, starch, crospovidone XL-10, pulverized, mixed, passed through a 100-mesh sieve, and used 1-2% hydroxyl Propyl methyl cellulose is granulated, passed through a 40-mesh sieve, dried at 30-55°C for 3-5 hours, passed through a 20-mesh sieve for granulation, and added with 1-4% crospovidone-XL and 0.5-1.0% hard Magnesium fatty acid, mixed evenly, tableted, each tablet weighs 200-400mg, contains 15mg of Muxiangweitai, which is equivalent to 0.5g of Muxiang crude drug, and the yield is 80-98%.

Embodiment 3

[0059] Example 3——Preparation of Muxiangweitai liquid-filled capsules

[0060] Prescription: Muxiang Weitai 100

[0061] Polyethylene glycol 4000 200~350

[0062] Polyethylene glycol 400 200~350

[0063] Operation: Mix the prescribed amount of polyethylene glycol 4000 and the prescribed amount of polyethylene glycol 400 evenly, melt at 55-75°C, slowly cool down to 40-50°C, add the prescribed amount of Muxiang Weitai, mix well, Keep it warm for 10-50 minutes, exhaust the air bubbles, and fill it into capsules with a liquid-filled capsule filling machine. Each capsule weighs 100-400 mg, contains 30 mg of Muxiang Weitai, which is equivalent to 1.0 g of Muxiang crude drug, and the yield is 80-98%.

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PUM

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Abstract

The invention discloses a preparation method of traditional Chinese medicine gastric motility medicine, which comprises the following steps: (a) extracting the effective part Muxiang Weitai from Muxiang; The total lactone content of Muxiangweitai raw material is determined by using hydrogen corylidene as a reference substance, and the standard Muxiangweitai raw material is obtained; (c) the Muxiangweitai raw material is prepared into a traditional Chinese medicine Weikine pharmaceutical preparation. Animal experiments show that the traditional Chinese medicine gastric motility drug obtained by the preparation method of the present invention is equivalent to morphine in promoting gastric motility and alleviating gastric motility disorders, and the analgesic effect is better than morphine, but there is no effect of morphine. side effect. The dosage is small and the price is very low.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine, in particular to a preparation method of a traditional Chinese medicine gastric motility drug capable of increasing human gastric motility. Background technique [0002] The representative drug of gastric motility drug is the chemical drug morphine tablet. It holds the number one market share in the drug market for patients with gastric dysmotility disorders. But the side effects of morphine are also obvious. Because patients with gastric motility disorder may have recurrent attacks, they often take repeated medications, and more attention should be paid to the side effects, such as dry mouth, rash, headache, dizziness, lassitude, lethargy, diarrhea, nervousness, lactation, and feminization of gynecomastia. Contents of the invention [0003] The purpose of the present invention is to provide a preparation method of traditional Chinese medicine gastric motility medicine, which can promote gast...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/289A61K36/285A61K9/20A61K9/48A61P1/14A61K125/00
Inventor 孔伶俐魏吉城
Owner GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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