Perhexiline injection and its preparing method

Abstract

The present invention discloses a Guanxinning injection for effectively curing coronary heart disease and ischemic cerebrovascular disease. It is characterized by that said injection is basically formed from tanshinone, salvia phenol acid matter, liguistrazine and ligusticum pherol acid ester matter. Besides, said invention also provides its preparation method by utilizing fresh salvia root and ligusticum root and its concrete steps. It is characterized by that the invented injection not only contains tanshinone II A and ligustrazine, but also contains cryptotanshinone, tanshinone I, salvia phenol acid matter and ligusticum phenol acid ester matter.

Description

technical field [0001] The invention relates to an injection for treating coronary heart disease and ischemic cerebrovascular disease and a preparation method thereof, in particular to an injection for treating coronary heart disease and ischemic cerebrovascular disease prepared by extracting salvia miltiorrhiza and Chuanxiong as raw materials Liquid belongs to the field of traditional Chinese medicine. Background technique [0002] Most of the injections currently on the market for the treatment of coronary heart disease and ischemic cerebrovascular disease are composed of Danshen and Chuanxiong. They are effective in treating coronary heart disease and ischemic cerebrovascular disease, and are one of the commonly used traditional Chinese medicine injections in clinic. The traditional preparation method of the injection is to mix Danshen and Chuanxiong decoction pieces together for three times of water extraction and secondary alcohol precipitation, then adjust the pH for a...

AI Technical Summary

Problems solved by technology

The traditional preparation method of the injection is to mix Danshen and Chuanxiong decoction pieces together for three times of water extraction and secondary alcohol precipitation, then adjust the pH for acidification treatment to obtain Xinnaoning injection (CN1457784A) composed of Danshen and Chuanxiong extracts. Although Ligustrazine can be made into salt to increase its water solubility, but the main active ingredients in Salvia miltiorrhiza, such as salvianolic acid, salvianolic acid A, salvianolic acid C, etc., will reduce the water solubility under acidic conditions. properties, and even precipitate, so that the curative effect of the injection prepared by this method is affected. At the same time, the dry slices are extracted with water for 3 times, and the active ingredients cannot be extracted completely. , Ligustrazine and other components in Chuanxiong can not be completely extracted, but also make the phenolic esters in Chuanxiong, such as ligustilide, dimer ligustilide, chrysophanol, caffeic acid, protocatechuic acid , ferulic acid, etc. cannot be completely extracted; the type and content of active ingredients in the injection are reduced, which directly affects the therapeutic effect of the prepared injection