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Medicine for promoting blood circulation and relaxing the bowels and its preparing method

A technology of medicine and Qiang living, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of less obvious effect of internal heat symptoms after yin deficiency, no effect of promoting blood and nourishing blood, and not being able to be taken for a long time, so as to overcome irritation. and limitations of defects, make up and have no effect of promoting blood and nourishing blood, and the effect of reliable curative effect

Active Publication Date: 2008-08-06
CHENGDE TRADITIONAL CHINESE MEDICINE GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, Maziren Pill is a medicine for clearing away bitter cold, and it is easy to injure body fluid and consume liquid for a long time, but has no effect of promoting blood and nourishing blood; Cistanche laxative oral liquid has little effect on the symptoms of internal heat after yin deficiency; Tongtai capsule and rhubarb Soda tablets are easy to cause colic and should not be taken for a long time; although the dosage form of Maren Soft Capsule has been improved, it still has no effect of promoting blood circulation and nourishing blood

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1, medicine for promoting blood circulation and moistening intestines and its preparation.

[0021] Raw material medicine prescription: by weight, wherein, 9-12 parts of rhubarb, 22-30 parts of hemp seed, 9-12 parts of angelica, 18-24 parts of peach kernel, 13-18 parts of melon basket, 4-6 parts of windproof , Notopterygium 9-12 parts.

[0022] Preparation method: after weighing the bulk drug according to the proportioning weight, it is completed through the following steps:

[0023] (1) After crushing Angelica, Fangfeng and Notopterygium into coarse powder, use supercritical carbon dioxide under the process conditions of extraction pressure 18-22Mpa, extraction temperature 62-68℃, analysis pressure 5.5-6.5Mpa, analysis temperature 28-32℃ Extract for 3.5-4.5 hours to obtain extract a, extract the medicinal residue with 3-5 times the amount of 70% ethanol for 2.5-3.5 hours twice to obtain medicinal liquid a, and concentrate medicinal liquid a to a relative densi...

Embodiment 2

[0028] Example 2, the preferred preparation method of blood-activating and intestinal-relieving medicine.

[0029] The optimal composition of raw materials: in parts by weight, 10 parts of rhubarb, 25 parts of hemp seed, 10 parts of angelica, 20 parts of peach kernel, 15 parts of melon basket, 5 parts of Fangfeng, 10 parts of notopterygium

[0030] The best preparation method: after weighing the bulk drug according to the proportioning weight, it is completed through the following steps:

[0031] (1) After crushing Angelica, Fangfeng and Notopterygium into coarse powder, use supercritical carbon dioxide to extract for 4 hours under the process conditions of extraction pressure 20Mpa, extraction temperature 65°C, analysis pressure 6Mpa, analysis temperature 30°C to obtain extract a, which The dregs were extracted twice with 4 times the amount of 70% ethanol for 3 hours to obtain medicinal liquid a, and the medicinal liquid a was concentrated to a relative density of 1.15;

[0...

Embodiment 3

[0036] Example 3, the preparation of Huoxue Runchang Soft Capsules.

[0037] Raw material prescription: by weight in g, rhubarb 10g, hemp seed 25g, angelica 10g, peach kernel 20g, melon basket 15g, windproof 5g, notopterygium 10g.

[0038] Preparation method: carry out the same steps as (1), (2), (3), and (4) of Example 2 after weighing the raw material drug according to the proportioning weight of the raw material drug composition, and then:

[0039] (5) Take an appropriate amount of soybean oil and beeswax, heat to melt at 80°C, then add extract a, extract b and medicinal powder, mix well, and make 1000 soft capsules.

[0040] Because the soft capsule has high bioavailability, and can cover the bad smell of the medicine, reduce irritation, increase the stability of the medicine, prevent the oxidation and decomposition of the medicine, etc., and the medicine of the present invention contains a large amount of oil, after mixing with the extract It can be made into a paste and...

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Abstract

The present invention provides a kind of medicine for promoting blood circulation and relaxing the bowels and its preparation process. The medicine is prepared with rhubarb, hemp seed, angelica, peach kernel, Mongolian snake gourd seed, ledebouriella root and notoperygium root in certain weight proportion. The preparation process includes the following steps: crushing angelica, ledebouriella root and notoperygium root and supercritical CO2 extraction to obtain extract A, and alcohol extraction of the dregs to obtain medicine liquid A; crushing Mongolian snake gourd seed, peach kernel and hemp seed and supercritical CO2 extraction to obtain extract B; alcohol extraction of rhubarb to obtain medicine liquid C; mixing medicine liquid A, medicine liquid C and fine silicon gel powder, and spray drying to obtain medicine powder; mixing the medicine powder, the extract A and the extract B; and further treatment to form different preparation forms. The medicine is used to treat constipation mainly.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a medicine for promoting blood circulation and soothing intestines for treating constipation and a preparation method thereof. Background technique: [0002] Constipation is a common disease in the anorectal department. According to data, the incidence rate of constipation in the United States is 2%, the United Kingdom is 10%, Japan is 4%, Tianjin is 4.4%, and Beijing is 6.07%. Among them, women are significantly higher than men, accounting for 9.68% and 2.11%; According to statistics, more than 50% of the elderly suffer from constipation. Western medicines clinically used to treat constipation mainly include phenolphthalein, Kaisailu and Tongtaiyin. In addition, Febibran produced by RecipAB in Sweden and polyethylene glycol 4000 (Fusong) listed by Bofu-Ipsen in France have also begun to be used for the treatment of constipation. It can be seen ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61K36/708A61K36/60A61K36/428A61K36/238A61K36/237A61K36/232A61K9/02A61K9/16A61K9/20A61K9/48A61P1/10
Inventor 李卫民李沈明王春民刘书堂郭金甲黄飞龙阎春风董海荣党晓伟
Owner CHENGDE TRADITIONAL CHINESE MEDICINE GROUP
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