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Pharmaceutical composition for treating constipation, its formulation and preparation process thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition for treating constipation and its preparation and preparation, which can solve problems such as easy relapse and can not fundamentally solve constipation symptoms, so as to achieve the goal of not recurring easily, improving immunity and disease resistance , the effect of reducing the chance of constipation

Active Publication Date: 2008-04-16
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Plantago plant is the first-selected medicine as the volumetric medicine for treating constipation. When taking Plantago plant medicine alone to treat constipation, although the side effects are small, it can only temporarily relieve constipation symptoms. Relieves symptoms of constipation

Method used

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  • Pharmaceutical composition for treating constipation, its formulation and preparation process thereof

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Experimental program
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Effect test

Embodiment 1

[0043] Dry psyllium seed powder and methylcellulose at 50°C for 3 hours, grind them finely, pass through a 100-mesh sieve, and expose them to ultraviolet light for 2 hours; dry fructooligosaccharides at 50°C for 2 hours, grind finely, Pass through a 100-mesh sieve; fully mix 15.5g of psyllium powder and 5g of methylcellulose, pass through a 90-mesh sieve, add 75.5g of fructooligosaccharides, mix well, and sieve. With appropriate amount of 10% povidone K 30 Ethanol solution is used as a binder to make a suitable soft material, granulated with a 20-mesh sieve, dried in an oven at 60°C for 2 hours, granulated, added with 2.0g of magnesium stearate, mixed evenly, round punched tablets, qualified after inspection, and packaged.

Embodiment 2

[0045] Dry plantain seed powder and hydroxypropyl cellulose at 50°C for 3 hours, grind them finely, pass through a 100-mesh sieve, and expose them to ultraviolet light for 2 hours; dry stachyose at 50°C for 2 hours, grind finely, Pass through a 100-mesh sieve; fully mix 10g of psyllium seed powder and 5g of hydroxypropyl cellulose, pass through a 90-mesh sieve, add 80g of stachyose, mix well, and sieve. Take the appropriate amount of 8% povidone K 30 Ethanol solution is used as a binder to make a suitable soft material, granulated with a 20-mesh sieve, oven-dried at 60°C for 2 hours, granulated, added with 1.0g of magnesium stearate, mixed evenly, round punched tablets, qualified after inspection, and packaged.

Embodiment 3

[0047] Dry psyllium gum and carboxymethyl cellulose at 50°C for 3 hours, grind them finely, pass through a 100-mesh sieve, and expose them to ultraviolet light for 2 hours; dry galactooligosaccharides at 50°C for 2 hours, grind them , through a 100-mesh sieve; fully mix 20g psyllium gum and 8g carboxymethyl cellulose, pass through a 90-mesh sieve, add 70g galacto-oligosaccharides, mix well, and sieve. With appropriate amount of 12% povidone K 30 Ethanol solution is used as a binder to make a suitable soft material, granulated with a 20-mesh sieve, oven-dried at 60°C for 2 hours, granulated, added with 1.0g of magnesium stearate, mixed evenly, round punched tablets, qualified after inspection, and packaged.

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Abstract

The invention provides a pharmaceutical composition for treating constipation, its formulation and preparation process, wherein the pharmaceutical composition comprises Plantago spp. Plants and functional oligosaccharide, and is prepared into solid preparation for oral administration.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating constipation, its formulation and preparation method, in particular to a pharmaceutical composition composed of plants of the genus Plantago and functional oligosaccharides, its preparation and preparation method. Background technique [0002] Constipation is one of the common clinical symptoms. A survey shows that 10% of the population suffers from this disease, and its incidence increases with age. Patients with constipation also increase the risk of colon cancer, especially the elderly often have heart and cerebrovascular diseases. disease, which is even more dangerous if accompanied by constipation. [0003] At present, the medicines for clinically treating constipation can be roughly divided into three categories, mainly stimulant laxatives (such as rhubarb, senna, phenolphthalein, etc.), lubricating laxatives (such as glycerin) and volumetric laxatives (such as psyllium). [0004...

Claims

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Application Information

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IPC IPC(8): A61K36/68A61K31/715A61K9/20A61K9/48A61K9/16A61P1/10
Inventor 腾厚雷李敏吴巍裴红田京伟刘志峰
Owner SHANDONG LUYE PHARMA CO LTD
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