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Application of cucoline in preparation of medicine for treating macular degeneration, pigmentary degeneration of retina and diabetes retinosis

A technology of diabetic retina and retinal pigment, which is used in drug combination, sensory disease, pharmaceutical formulation, etc.

Inactive Publication Date: 2008-04-02
王爱玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no effective pharmacological treatment other than systemic hypoglycemia

Method used

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  • Application of cucoline in preparation of medicine for treating macular degeneration, pigmentary degeneration of retina and diabetes retinosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 25000 mg of sinomenine hydrochloride powder was purchased from Wuhan Zhonglian Pharmaceutical Factory, 250 g of medicinal starch, granulated with an appropriate amount of alcohol, and dried. Enter the tabletting machine and compress into tablets to make 1000 tablets. Each tablet weighs 275mg and contains 25mg of sinomenine hydrochloride.

Embodiment 2

[0022] Sinomenine 20000mg, starch 180g, the two are fully mixed, packed into capsules, made into 2000 capsules, each weighing 0.1g, containing 10mg of sinomenine hydrochloride.

experiment example 2

[0073] Treatment group 3: The number of positive microglia stained for CD11b in the outer layer was significantly less than that of the model control group, and more than that of treatment group 2. Experimental example 2 Sinomenine inhibits the activation of retinal microglial cells induced by non-enzymatic glycosylation products (AGEs)

[0074] Microglia is a separate group of migrating macrophages in the central nervous system (CNS), which has its own particularity in terms of structure, characteristics and cell lineage, and its function is quite active, accounting for about 100% of the total number of glial cells. 10-20%. There are two types of retinal microglia: stromal microglia and perivascular microglia. Microglia generally exist in two different forms: resting microglia and activated microglia. Under normal circumstances, it manifests as static branching, and the immune activity is down-regulated. Activated when various pathological events occur. Activated microgli...

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Abstract

An application of tuduranine in treating the nervous degenerations of rectina, such as age-related macular degeneration, pigmentary degeneration of retina, etc is disclosed.

Description

technical field [0001] The invention relates to a new application of a medicine, specifically the application of sinomenine in the preparation of medicines for treating age-related macular degeneration, retinitis pigmentosa and diabetic retinopathy. Background technique [0002] Sinomenine (SIN) is an alkaloid monomer extracted from the rhizome of the plant Sinomenium scutum Rehd.et Wils. It is a known medicinal substance with a chemical name of 7, 8-didehydro-4-hydroxy-3, 7-dimethoxy-17-methyl, (9α, 13α, 14α)-morphinan-6-one has a molecular formula of C19H23NO4 and a molecular weight of 329.38. The chemical structural formula is shown below. [0003] [0004] From the chemical structure point of view, SIN is composed of a hydrogen phenanthrene nucleus and an ethylamine bridge, and its structure is similar to that of morphine. This product is a filamentous crystal with a melting point of 161°C, easily soluble in chloroform, acetone, ether, and slightly soluble in water....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4748A61P27/02A61P25/02
Inventor 王爱玲曹安民
Owner 王爱玲
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