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Phacolysin eye medicinal formulation

A pharmaceutical preparation, facolin technology, applied in the field of ophthalmic pharmaceutical preparations, can solve the problems of low product stability, irritation, affecting product quality, etc., and achieve the effects of excellent effect, few side effects and simple preparation method.

Active Publication Date: 2008-02-27
武汉五景药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Existing Falkolin products use solution formulations. Because some cosolvents and stabilizers are added, the product has certain irritation. Quality of products

Method used

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  • Phacolysin eye medicinal formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1. Tablet prescription

[0047] Dosage per 10,000 tablets

Facolin

15g

Bulking agent (taurine)

1000g

boric acid

200g

ethanol

100ml

Water for Injection

70ml

[0048] 2. Process

[0049] (1) Pulverization: respectively pulverize Factoline, filler and boric acid through a 60-100 mesh sieve;

[0050] (2) Take ethanol, add water for injection to make it diluted to 40%~60% ethanol liquid, as adhesive;

[0051] (3) Mixing: Add the falcolein, filler and boric acid into the mixing granulator and mix. First dry mix for 8-15 minutes, then add binder and wet mix for 2-5 minutes to make a soft material;

[0052] (4) Granulation: Pass the soft material through a No. 10-14 sieve to granulate;

[0053] (5) Drying: 40~75℃, dry for 3~8 hours;

[0054] (6) Grain sizing: pass through No. 12 to No. 16 sieves after drying;

[0055] (7) Total mixing: 5 to 20 minutes;

[0056] (8) tableting;

[0057] (9)...

Embodiment 2

[0071] Solvent formulation

[0072] Consumption per 10,000 sticks

[0073] The preparation method is the same as in Example 1.

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PUM

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Abstract

The present invention relates to a Fakelin eye medicine preparation. Said preparation includes medicinal active component Fakelin and solvent. Said active component Fakelin can be made into independent solid preparation, and is separated from the solvent. Said active component Fakelin and solvent are packaged separately, when it is used, the solid preparation Fakelin can be dissolved in the solvent, so that it can produce the action of stabilizing preparation.

Description

Technical field: [0001] The invention relates to an ophthalmic pharmaceutical preparation, in particular to an ophthalmic pharmaceutical preparation of falkolin. Background technique: [0002] Phacolin, English name: Phacolin, chemical name: 5,12-dihydro-5,7,12,14-tetraazapentacene 2,9-sodium disulfonate. [0003] The structural formula is: [0004] [0005] Molecular formula: C 18 h 10 N 4 Na 2 o 6 S 2 [0006] Molecular weight: 488.41 [0007] Fakolin is a proteolytic enzyme activator, which can activate protein decomposition. As eye drops, it can prevent cataracts. Fakolin can penetrate into the lens after eye drops, decompose and absorb denatured proteins, and maintain the lens. Transparent, improves the metabolism of eye tissue, and can prevent the development of cataract. [0008] Existing Falkolin products use solution formulations. Because some co-solvents and stabilizers are added to the product, the product has certain irritation. Quality of products....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/08A61K31/4985A61J1/00A61P27/12
Inventor 范先甲范新兰
Owner 武汉五景药业有限公司
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