The invention relates to the field of medical devices, and discloses a patellofemoral joint prosthesis and a manufacture method thereof. The patellofemoral joint prosthesis comprises a femur trochleaprosthesis body and a patella prosthesis body, wherein the femur trochlea prosthesis body comprises an internal condyle, an external condyle and a trochlear groove. The internal condyle and the external condyle are located on the two sides of the femur trochlea prosthesis body, and the trochlear groove is connected with the internal condyle and the external condyle, wherein the internal condyle and the external condyle are in cambered connection with the trochlear groove at different curvature radii, so that the junction surface formed by the internal condyle, the external condyle and the trochlear groove together forms a cooperative curved surface which cooperates with the patella prosthesis body. The femur trochlea prosthesis body further comprises a fixing surface which is formed on thefemur trochlea prosthesis body and is opposite to the cooperative curved surface, and a fixing assembly is formed on the fixing surface. The patella prosthesis body comprises a curved joint surface which cooperates with the cooperative curved surface, the top view of the section of the curved joint surface is elliptical, the front view of the section is in an unsymmetrical parabolic shape, and aconnection column is formed on the face, opposite to the curved joint surface, of the patella prosthesis body. The patellofemoral joint prosthesis is more suitable for Chinese in use.