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Myelin oligodendrocyte glycoprotein-specific peptide for the treatment or prevention of multiple sclerosis

a technology of myelin oligodendrocytes and glycoproteins, which is applied in the direction of peptide/protein ingredients, antibody medical ingredients, drug compositions, etc., can solve the problems that the therapy fails to stop autoimmune attacks in the cns, and achieve the effect of preventing or preventing

Inactive Publication Date: 2019-08-15
LOMA LINDA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a composition and method for treating multiple sclerosis (MS) using a peptide that activates immune cells. The peptide is a partial amino acid sequence of myelin oligodendrocyte glycoprotein (MOG) and specifically targets HLA-E-restricted regulatory CD8+ T cells. The composition can be administered as a peptide or pulsed onto dendritic cells for better immune cell activation. The method of treatment involves administering the composition to a subject with MS to help regulate the immune response and reduce inflammation in the central nervous system. The composition can also be used to treat other demyelinating diseases such as multiple sclerosis, idiopathic inflammatory demyelinating disease, and optic neuritis. The treatment is safe and effective, and can be administered through subcutaneous or intravenous routes.

Problems solved by technology

However, currently available therapies still fail to halt autoimmune attacks in the CNS.

Method used

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  • Myelin oligodendrocyte glycoprotein-specific peptide for the treatment or prevention of multiple sclerosis
  • Myelin oligodendrocyte glycoprotein-specific peptide for the treatment or prevention of multiple sclerosis
  • Myelin oligodendrocyte glycoprotein-specific peptide for the treatment or prevention of multiple sclerosis

Examples

Experimental program
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Effect test

example 1

Non-Classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis

Methods

[0078]Mice:

[0079]C57BL / 6 (B6) and Kb− / −Db− / − mice were obtained from Taconic Farms and housed in a specific pathogen-free animal facility at the University of Texas at El Paso (UTEP) or Loma Linda University (LLU). All experiments were done in compliance with an Institutional Animal Care and Use Protocol approved by UTEP and / or LLU Animal Care and Use Committee.

[0080]Cell Lines:

[0081]C1R is a human B lymphoblastoid cell line. C1R.Qa-1b is a stable transfectant that constitutively expresses Qa-1b. DC2.4 is a DC line generated from bone-marrow-derived DCs.

[0082]Reagents:

[0083]Peptides used m this study were synthesized at Genemed Synthesis, Inc., San Antonio, Tex.

[0084]IFN-γ Enzyme-Linked Immunospot (EL / SPOT) Assay:

[0085]ELISPOT plates were coated with an anti-mouse IFN-γ mAb (5 μg / ml in PBS) at 4° C. overnight, blocked with culture medium for 2 hours at room temperature, and added with desired numb...

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Abstract

Compositions for the treatment or prevention of multiple sclerosis are provided. In some embodiments, the composition comprises an isolated peptide comprising a partial amino acid sequence of a myelin oligodendrocyte glycoprotein (MOG) protein, wherein the peptide activates regulatory T cells. In some embodiments, the composition comprises dendritic cells pulsed with a MOG peptide that activates regulatory T cells. In some embodiments, the peptide activates HLA-E-restricted regulatory CD8+ T cells.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application No. 62 / 357,891, filed Jul. 1, 2016, the entire content of which is incorporated by reference herein.BACKGROUND OF THE INVENTION[0002]Multiple sclerosis (MS) is a chronic and often debilitating disorder of the central nervous system (CNS). Data suggest that MS global prevalence and incidence rate are increasing (Melcon et al., Journal of the Neurological Sciences, 2014, 344:171-181). It is believed that MS is caused by attacks on the myelin sheath by one's own immune system.[0003]Studies in MS autoimmune animal models (experimental autoimmune encephalomyelitis, or EAE) have led to a series of FDA-approved medications that have significantly slowed disease progression and improved patients' quality of life. However, currently available therapies still fail to halt autoimmune attacks in the CNS. There remains a need for methods of treating MS.BRIEF SUMMARY OF THE INVENTI...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K14/705A61P25/00C07K14/74A61K9/00A61K35/15
CPCC07K14/70503A61P25/00C07K14/70539A61K9/0019A61K35/15C07K2319/00A61K38/00A61K39/39541C07K16/2815A61K2039/505A61P25/28C12N5/0637A61K38/1709A61K39/4621A61K39/4622A61K2239/31A61K39/4615A61K2239/38A61K39/46433A61K2300/00C07K14/4713
Inventor TANG, XIAOLEIBAYLINK, DAVID J.
Owner LOMA LINDA UNIVERSITY
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