Effects of a decaffeinated green coffee extract on body weight control by regulation of glucose metabolism

Abstract

A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 4-caffeoylquinic acid (4-CQA) to total chlorogenic acids (tCGA) (5-CQA / tCGA) of from about 0.1 to about 0.2. More preferably, the green coffee extract comprises from about 6% to about 8% of 4-caffeoylquinic acid and has a total chlorogenic acid concentration that exceeds about 45%. A preferred method of administration consists of administering the green coffee extracts is a dosage of about 200 mg twice a day prior to meals on an empty stomach.

Description

[0001]This application is a continuation-in-part and claims the benefit of a non-provisional U.S. patent application Ser. No. 12 / 263,292 filed on Oct. 31, 2008.FIELD OF THE INVENTION[0002]The present invention relates to dietary supplements comprising a green coffee extract and methods relating to the administration of green coffee extract.BACKGROUND OF THE INVENTION[0003]The prevalence of obesity (BMI≧30 kg / m2) continues to be a health concern for adults, children and adolescents in the United States. Data from the NHANES survey shows that among adult men the prevalence of obesity increased from 31.1% in 2003-04 to 32.2% in 2007-08, a small but not statistically significant change. Among adult women, the prevalence of obesity increased from 33.2% in 2003-04 to 35.5% in 2007-08, again a small but not significant change (Ogden et al. Gastroenterology 2007; 132 (6):2087-2102; Flegal et al. JAMA 2009; 303 (3):235-241). In Europe, the prevalence of obesity has increased by 10 to 38%, de...

AI Technical Summary

Benefits of technology

[0017]Broadly, the present invention is directed to methods of using green coffee extract, such as Svetol® brand green coffee extract (commercially available from NATUREX S.A., Avignon France), to inhibit the Glc-6-Pase system, reduce glycemia and promote reduced body fat, increase Muscle Mass / Fat Mass ratio (MM / FM) in the body, and reduce the body weight and body mass index (BMI) in humans. One aspect of the invention is directed to a method of improving body weight in humans and reducing the risk of Type 2 diabetes (T2D) by administering an amount of green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 5-caffeoylquinic acid (5-CQA) to total chlorogenic acids (tCGA) (5-CQA / tCGA) of from about 0.2 and 0.3. More preferably, the concentration of tCGA is greater than about 45% and the concentration of 5-CQA is less than about 10%. A preferred method of administration consists of administering between about 200 mg and about 1,000 mg per day, more preferably administering about 400 mg per day. In one embodiment, the green coffee extract is administered to a subject in a dosage of between about 200 mg and about 1,000 mg per day of green coffee extract.

[0019]The inventors believe they are the first to have discovered that one can use a green coffee extract for the inhibition of the Glc-6-Pase system. The inhibition of the Glc-6-Pase system is favored by the ratio existing between 5-CQA and tCGA in the green coffee extract. For the first time, it is demonstrated that not only 5-CQA inhibits the Glc-6-Pase system, but also other CGA present in the green coffee extract. This specially designed green coffee extract is more effective in inhibiting the Glc-6-Pase system than the combination of isolated CGA, evidencing a greater level of synergy between all natural CGA present in the extract.

[0021]In one embodiment of the invention, the bioavailability of CGA in humans is defined from the specially designed green coffee extract of the present invention. Data on the bioavailability of CGA from green coffee in humans was previously nonexistent. The special composition in the green coffee extract allows that three CQA, three diCQA and caffeic, ferulic, isoferulic and p-coumaric acids are bioavailable in plasma; and 4-CQA, 5-CQA and sinapic, p-hydroxybenzoic, gallic, vanillic, dihydrocaffeic, caffeic, ferulic, isoferulic, and p-coumaric acids in urine. Therefore, the CGA in the green coffee extract, which is also able to inhibit the Glc-6-Pase system activity, is bioavailable in humans as evidenced in plasma and urine.

[0022]In another embodiment of the invention, a green coffee extract (Svetol® green coffee extract, NATUREX) is applied and able to reduce glycemia in humans.

[0023]In another embodiment of the invention, a green coffee extract (Svetol® green coffee extract, NATUREX) is applied and able to reduce body fat in humans.

[0025]In another embodiment of the invention, a green coffee extract (Svetol® green coffee extract, NATUREX) is applied and able to reduce body weight in humans.

Problems solved by technology

In addition, the choice of raw material and the extraction conditions provide an extract containing no cafestol or kahweol, constituents of coffee which can increase the risk of cardiovascular disease.

Images