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Mixture of non-digestible oligosaccharides for stimulating the immune system

Inactive Publication Date: 2012-07-12
NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015]Recently, new techniques have become available to chemically synthesise specific types of NDO identical to specific human NDO, thereby offering the opportunity to test the immunomodulatory capacity of specific human NDO in in vitro and in vivo assays.
[0018]The present combination is especially advantageous for human subjects having a reduced Th1 response in comparison with healthy adults, in particular newborn infants, elderly humans suffering from immunosenescence, humans suffering from AIDS or being infected with the Human Immunodeficiency Virus, and cancer patients that are or have been subjected to chemotherapy, radiation and cancer patients that are cachectic.

Problems solved by technology

Because of their complex and polymorphic structure, large-scale synthesis is complicated.
It is therefore not yet technically and economically feasible to prepare infant nutrition with an NDO composition identical to human milk.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0058]The effect of diets comprising 2′-FL and / or betagalacto-oligosaccharides was tested in a mouse model wherein a response to an antigen is measured by a delayed-type hypersensitivity (DTH) response. This DTH response in the ears after local challenge with an antigen present in a vaccine is a measure of Th1 cell proliferation. During response to infection and / or vaccination Th1 cells proliferate in response to the challenge with the antigen. These Th1 cells infiltrate the ear when the ear is subsequently challenged with the antigen and cause swelling. Infiltration with the Th1 cells in the ear takes about 24 h and the swelling is therefore delayed. The more Th1 cells proliferated during initial vaccination and / or infection, the more DTH upon challenging with the antigen is observed.

Materials and Methods

[0059]6-8 Weeks old female C57BL / 6 mice (Charles River) received semi-purified AIN-93G-based diets (Research Diet Service, Wijk bij Duurstede, the Netherlands), comprising

[0060]1) ...

example 2

[0069]Infant formula for stimulating immune system comprising per 100 ml (13.9 dry weight):

[0070]1.4 g protein (whey and casein)

[0071]7.3 g digestible carbohydrates (including lactose)

[0072]3.6 g fat (vegetable fat, fish oil)

[0073]0.8 g non-digestible oligosaccharides of which 80 mg 2′-fucosyllactose and 640 mg beta-galacto-oligosaccharides, and 80 mg fructo-oligosaccharides

[0074]Further are included: choline, myo-inositol, taurine, minerals, trace elements, and vitamins as known in the art.

example 3

[0075]Infant formula for stimulating immune system comprising per 100 ml (13.9 dry weight):

[0076]1.4 g protein (whey and casein)

[0077]7.3 g digestible carbohydrates (including lactose)

[0078]3.6 g fat (vegetable fat, fish oil)

[0079]0.8 g non-digestible oligosaccharides of which 40 mg 2′-fucosyllactose and 760 mg beta-galacto-oligosaccharides, fructo-oligosaccharides and uronic acid oligosaccharides in a 9:1:1.2 wt / wt ratio.

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Abstract

Nutritional compositions with fucosyllactose and betagalactooligosaccharides for use in stimulation of the immune system. The composition is suitable for infants.

Description

FIELD OF THE INVENTION [0001]The present invention relates to nutrition with a mixture of non-digestible oligosaccharides, and in particular to the use thereof for stimulating the immune system.BACKGROUND OF THE INVENTION[0002]Human milk fed infants have a lower incidence of infections, including viral infections, than formula fed infants. Many components in human milk, including immunoglobulins (such as IgA), interleukin (IL)-1, IL-6, IL-8, IL-10, interferon-γ(IFN-γ), immunocompetent cells, transforming growth factor-β (TGF-β), lactoferrin, nucleotides, and non-digestible oligosaccharides (NDO) are thought to be involved in protection against infection with enteric or respiratory pathogens.[0003]NDO are a major constituent of human milk and are a major element of the innate immune system of human milk. Human NDO promote the growth of a beneficial microbiota dominated by bifidobacteria and lactobacilli. Some human NDO are also known to be able to prevent directly the adhesion of pat...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P37/06A61P37/04A61P31/00A61K38/02A61P3/02A23L33/00
CPCA23L1/296C12N2760/16234A23V2002/00A61K31/702A61K39/145A61K2039/5252C12N2760/16111C12N2760/16211A23L1/30C12N2760/16134A61K2039/57A61K2039/55A61K2300/00A23V2250/54252A23V2250/54246A23V2250/28A23V2250/612A23V2250/18A23V2250/0644A23V2250/304A23V2250/70A23V2250/156A23V2200/324A23V2250/5046A61K39/39A61K2039/55511A23V2200/302A23V2200/308A23V2250/284A61K39/12A23L33/40A23L33/10A61P11/02A61P11/06A61P17/00A61P3/02A61P31/00A61P37/04A61P37/06A61P37/08
Inventor STAHL, BERNDNAUTA, ALMA JILDOUGARSSEN, JOHANSAMAIN, ERICDROUILLARD, SOPHIE
Owner NUTRICIA
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