Unextracted tooth root canal filler and dental tissue regeneration method for unextracted tooth

Abstract

Disclosed is a root canal filler for non-extracted tooth which causes no internal resorption or external resorption in a tooth with complete root formation, shows no odontoclast, and contributes to the regeneration of a dental tissue in which odontoblasts are smoothly aligned on the dentin wall. After pulpectomy or enlargement / cleaning of an infected root canal, a root canal filler for non-extracted tooth, which comprises tooth pulp stem cells and an extracellular matrix, is inserted into the apical side of the root canal of the non-extracted tooth. The tooth pulp stem cells may be, for example, dental pulp CXCR4-positive cells. It is preferred to attach, to the crown side of the root canal, migration factor(s) including at least one factor selected from among a cell migration factor, a cell proliferation factor, a neurotrophic factor and an angiogenic factor.

Description

TECHNICAL FIELD[0001]The present disclosure relates to unextracted tooth root canal fillers for filling root canals of unextracted teeth, and dental tissue regeneration methods for unextracted teeth using the unextracted tooth root canal fillers.BACKGROUND ART[0002]At present, about a half of tooth loss is due to dental caries and tooth fractures, and it is known that removal of dental pulp greatly increases the possibility of tooth loss.[0003]The average lifetime of teeth is said to be 57 years at present. To enable a person to chew with his / her own teeth throughout the lifetime, the lifetime of teeth needs to be prolonged by 20 years or more. Despite of “8020” Campaign (to keep 20 teeth or more until 80 years old), people now aged 80 keep about 8 teeth on average, and the number of remaining teeth of elderly people has hardly increased. Thus, dental caries treatment requires drastic improvement.[0004]When dental pulp is removed (pulpectomy), its potential of reparative dentin form...

AI Technical Summary

Benefits of technology

[0043]According to the present disclosure, dental tissues can be regenerated in a tooth with a complete apical closure, causing neither internal resorption nor external resorption and no odontoclasts, and exhibiting alignment of odontoblasts along the dentinal wall.

Problems solved by technology

At present, about a half of tooth loss is due to dental caries and tooth fractures, and it is known that removal of dental pulp greatly increases the possibility of tooth loss.

Thus, dental caries treatment requires drastic improvement.

When dental pulp is removed (pulpectomy), its potential of reparative dentin formation and defense mechanism against infection are lost, and an alarm signal, i.e., a pain, is lost, thereby increasing the danger of enlarged dental caries.

In addition, there are no perfect methods for the pulpectomy treatment, and leakage from a tooth crown part after pulpectomy and root canal filling might cause a periapical lesion, a vertical fracture, an aesthetic loss, and a postoperative pain.

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