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Stent and Method For Fabricating the Same

a technology of stent and stent body, which is applied in the field of stent, can solve the problems of repeated stenosis and high probability of restenosis, and achieve the effect of preventing restenosis

Inactive Publication Date: 2009-01-01
TOYO ADVANCED TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a stent with a drug release polymer coated on a diamond-like carbon film (DLC film) on its surface. The stent is designed to prevent restenosis, a common problem in angioplasty treatment. The DLC film is a smooth and chemically inert film that is compatible with the organism and can be used as a coating material for stents to reduce the occurrence of occlusion. However, conventional stents have limitations in continuously releasing the drug due to peeling off of the coating. The invention solves this problem by immobilizing a drug release polymer on the surface of the DLC film with a functional group introduced into a surface portion of the DLC film. This results in a stent that can continuously release the drug and prevent restenosis. The stent is minimally degraded by biogenic components and the drug can be gradually released from the stent, providing a long-term solution for preventing restenosis.

Problems solved by technology

In employing this treatment method, however, stenosis (restenosis) is repeatedly caused in high probability.
In the case where the restenosis occurs, it is necessary to perform the PTCA again, and it is a global problem of great urgency to establish methods for preventing and treating the restenosis.

Method used

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Examples

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example

[0105]The stent of the present invention will now be described in detail by describing a specific example. In this example, a Co—Cr alloy stent having a length of 19 mm, a diameter of 1.5 mm and a cell thickness of 75 μm was used as the stent body 11.

[0106]FIG. 2 schematically shows an ionization evaporation system used in this example, and this is a general ionization evaporation system in which a DLC film is solidified and deposited on a target 22 by colliding, against the target 22 biased to a negative voltage, plasma generated by introducing Ar and benzene (C6H6) gases corresponding to ion sources into a DC arc discharge plasma generator 21 provided within a vacuum chamber.

[0107]A stent body 11 was set within the chamber of the ionization evaporation system of FIG. 2, and bombardment cleaning, in which Ar ions are produced by discharging after introducing an argon gas (Ar) into the chamber so as to attain a pressure of 10−1 Pa through 10−3 Pa (10−3 Torr through 10−5 Torr) and th...

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Abstract

A stent includes a tubular stent body 11, a diamond-like carbon film 12 formed on the surface of the stent body 11 and having an activated surface, and a polymer layer 13 immobilized on the surface of the diamond-like carbon film. The polymer layer 13 contains a drug 14 having an effect to prevent restenosis, and the drug 14 is gradually released from the polymer layer 13.

Description

TECHNICAL FIELD[0001]The present invention relates to a stent and a method for fabricating the same, and more particularly, it relates to a drug release stent and a method for fabricating the same.BACKGROUND ART[0002]In accordance with recent westernization in the lifestyle, ischemic heart diseases (including angina pectoris and cardiac infarction) are rapidly increasing in Japan. An ischemic heart disease is caused principally when coronary thrombosis or coronary twitch is caused additionally to an arteriosclerotic disease of a thick coronary artery extending on the heart surface.[0003]As a treatment method for angiostenosis, angioplasty (PTA, PTCA or the like) in which a small balloon is expanded within a blood vessel for the treatment is widely employed as a minimally invasive treatment. In employing this treatment method, however, stenosis (restenosis) is repeatedly caused in high probability. As a method for reducing the ratio of the restenosis, a stent placement technique is b...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/06
CPCA61F2/91A61F2250/0067A61L31/084A61L31/10A61L31/16A61L33/025A61L2300/416A61L2300/606A61L2420/08
Inventor NAKATANI, TATSUYUKIOKAMOTO, KEISHIYAMASHITA, SHUZOKOMURA, IKUOMORI, KOJI
Owner TOYO ADVANCED TECH CO LTD
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