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Peptides with antioxidant and antimicrobial properties

a technology of antioxidant and antimicrobial properties, applied in the direction of peptide/protein ingredients, peptide sources, metabolic disorders, etc., can solve the problems of airspace collapse, reduced lung compliance, impaired gas exchange, etc., to prevent lipid oxidation and/or microbial proliferation, reduce lung injury, and prevent spoilage of products

Inactive Publication Date: 2008-01-24
MCCORMACK FRANCIS X JR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides methods for inhibiting the oxidation of lipids, proteins, and other compounds, as well as treating conditions associated with microbial contamination, colonization, or infection. The invention also provides pharmacological compositions containing antioxidant or antimicrobial lung surfactant protein compounds for the prevention and treatment of acute lung injury, including adult respiratory distress syndrome and hyperoxic lung injury. The lung surfactant proteins can be used as ingredients of medications, foods, cosmetics, and medications to prevent lipid oxidation and microbial proliferation. The invention also provides novel peptides derived from rat and human lung surfactant proteins that have lipid oxidation inhibiting and antimicrobial properties. These peptides can be easily manufactured and are practical for therapeutic use or as ingredients in foods, cosmetics, and medications.

Problems solved by technology

The pathophysiological consequences of surfactant oxidation in humans and experimental animals exposed to hyperoxia include airspace collapse, reduced lung compliance and impaired gas exchange.
Exposure of surfactant to ambient oxygen and potent environmental oxidants such as ozone can result in peroxidation of unsaturated phospholipids, surfactant inactivation, airspace collapse and impaired gas exchange.

Method used

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  • Peptides with antioxidant and antimicrobial properties
  • Peptides with antioxidant and antimicrobial properties
  • Peptides with antioxidant and antimicrobial properties

Examples

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examples

Methods

Purification and Modification of Surfactant Proteins—Antioxidant Properties

[0168] Native SP-A and SP-D were isolated from the alveolar wash of rats which had been pretreated with intratracheal silica to enhance the collectin yield, in accordance with the method of Dethloff et al., Biochem. J. 233:111-118 (1986). After centrifugation, rat SP-D was purified by maltose-Sepharose affinity chromatography of the supernatant and rat SP-A was purified from the pellet by NaBr flotation, butanol extraction and mannose-Sepharose affinity chromatography, in accordance with the method of McCormack et al., J. Biol. Chem. 272:27971-27979 (1997). Mouse SP-D was used interchangeably with rat SP-D. All proteins were extensively dialyzed to remove residual EDTA. For some experiments, rat SP-A and rat SP-D were alkylated by incubation with 0.5 M iodoacetamide at 37° C. in the dark for 1 hr and then extensively dialyzed. The wild type and mutant recombinant SP-A, SP-D and MBP used in this stu...

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Abstract

One embodiment of the present invention is directed toward methods for inhibiting the oxidation of lipids, proteins, and other compounds. Another embodiment is directed toward methods for treating conditions associated with microbial contamination, colonization, and / or infection.

Description

[0001] This invention was made with government support under Grant No. HL-61612 awarded by the National Institutes of Health. The government has certain rights in the invention.BACKGROUND OF THE INVENTION [0002] The present invention relates generally to methods for reducing or preventing the oxidation of lipids or other molecules, and to methods for inhibiting or reducing microbial proliferation. Specifically, the present invention is directed to compositions and methods for treating oxidative lung injury and other oxidative disorders, and to methods for preventing oxidation of foods, cosmetics and medications. Additionally, the present invention is directed to compositions and methods for treating lung infection and other disorders caused by microbial infection. [0003] The lung is made up of a series of branching conducting airways that terminate in grape-like clusters of delicate gas exchanging airspaces called pulmonary alveoli. Maintenance of alveolar patency at end expiration ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/16A61P11/00A61P9/10A61K8/64A61K38/00A61K38/17A61Q17/00A61Q19/00A61Q19/08C07K14/705
CPCA61K8/64A61K38/1709A61K2800/522C07K14/705A61Q19/00A61Q19/08A61Q17/005A61P9/10A61P11/00
Inventor MCCORMACK, FRANCIS X. JR.
Owner MCCORMACK FRANCIS X JR
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