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Treating cystic fibrosis with antibiotics via an aerosol drug

an aerosol drug and cystic fibrosis technology, applied in the directions of aerosol delivery, dispersed delivery, heterocyclic compound active ingredients, etc., can solve the problem that the system has not been applied to the delivery of antibiotics to the lungs to treat cystic fibrosis

Inactive Publication Date: 2007-12-13
WYETH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these systems have not been applied to delivery of antibiotics to the lungs to treat cystic fibrosis.

Method used

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  • Treating cystic fibrosis with antibiotics via an aerosol drug
  • Treating cystic fibrosis with antibiotics via an aerosol drug
  • Treating cystic fibrosis with antibiotics via an aerosol drug

Examples

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Effect test

example

Tygacil®(Tigecycline) for Deep Lung Delivery

[0029] The commercial Tygacil®2nd Generation product was used to conduct the study. Sterile Water for injection and 0.9% Normal Saline were used at diluents. Tygacil® is a sterile, lyophilized powder for intravenous infusion, containing 53 mg of the Tigecycline active ingredient. Tygacil® additionally contains lactose monohydrate as a diluent / stabilizer and hydrochloric acid and / or sodium hydroxide (as needed) for pH adjustment. The product is supplied in a single dose; Type I, clear, glass vial, sealed under a blanket of nitrogen with a gray butyl rubber stopper and a snap-off aluminum crimp seal.

The Quantitative Composition of Tygacil® is Depicted in Table 1 Below.

[0030]

TABLE 1Quantitative Composition for Tygacil ®Reference toIngredientStandardsFunctionQuantity per VialTigecyclineaIn-HouseActive 53 mgMonographLactoseNF / Ph. Eur.bDiluent / 106 mgMonohydrateStabilizerHydrochloric AcidNF / Ph. Eur.pH AdjustmentQ.S. to adjust pHSodium Hydroxid...

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Abstract

A method of treating respiratory disorders by delivering antibiotic to the lung alveoli using an aerosol drug delivery system.

Description

[0001] This application claims priority from co-pending U.S. provisional application No. 60 / 811672 filed on Jun. 7, 2006.BACKGROUND OF THE INVENTION [0002] The present invention is directed to a method of treating respiratory disorders by delivering antibiotic to the lung alveoli. [0003] Known aerosol drug delivery systems include, for example, a unit dose dry-powder inhaler, a dry powder pulmonary device, a pressurized metered dose inhaler, a metered-dose inhaler, a nebulizer, and the like. However, these systems have not been applied to delivery of antibiotics to the lungs to treat cystic fibrosis. [0004] Some aerosol devices are capable of delivering the smaller droplet sizes needed for deep lung penetration. One commercially available example is the SWIRLER® aerosol drug delivery system which is described at amici-inc.com, and in U.S. Pat. Nos. 5,603,314, 5,630,409, 5,611,332 and 6,230,703, which patents are incorporated by reference herein. [0005] As described in greater detail...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/12A61K31/43A61K31/545
CPCA61K9/0078A61K31/545A61K31/43
Inventor TATAPUDY, HANUMANTHARAOSHAH, SYED M.
Owner WYETH LLC
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