Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method and composition for inhibiting post-surgical adhesions

a post-surgical adhesion and composition technology, applied in the direction of drug compositions, powder delivery, medical preparations, etc., can solve the problems of reducing the effect of dextran intraperitoneally, preventing post-surgical adhesion formation, and reducing the effect of said solution on the separation of the uterine cavity walls

Inactive Publication Date: 2003-04-24
REEVE LORRAINE E +1
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

62, that there is currently no effective treatment that prevents their recurrence.
The authors, on page 618, indicate that the use of Dextran intraperitoneally has limitations such as the reported tendency of HYSKON to support bacterial proliferation and concern over the anaphylactoid potential of dextran.
Second, since these aqueous solutions are liquids at room temperature and below and form a clear gel at body temperature, the use of said solutions to separate the uterine cavity walls will diminish or prevent post-surgical adhesion formation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method and composition for inhibiting post-surgical adhesions
  • Method and composition for inhibiting post-surgical adhesions
  • Method and composition for inhibiting post-surgical adhesions

Examples

Experimental program
Comparison scheme
Effect test

example 2

[0059] The following formation was prepared:

1 Ingredient Percent by Weight Poloxamer 407, NF 28.00 Pentoxifylline 0.40 Tromethamine (TRIS), USP 0.1091 Maleic Acid 0.1045 Sodium Hydroxide pellets, USP 0.0420 Sterile Water for Irrigation, USP 71.344

[0060] First, the water was weighed in a tared vessel. Second, the tromethamine, maleic acid and sodium hydroxide were added to the water and mixed for twenty minutes. The pH and osmolality of the solution were tested and found to be 7.6 and 39 mOsm / Kg, respectively. The solution was cooled to 6.degree. C. and the poloxamer was added to the solution over a two-hour period with constant stirring. The solution was stored under a nitrogen atmosphere at 4.degree. C. for fifteen hours to effect a reduction in the foam content of the solution. The solution was tested for pH, osmolality, and viscosity and the results were 7.4, 123 mOsm / kg and 360,000 centipoise at 30.degree. C., respectively. The solution was packaged into 30 cc serum vials, cappe...

example 3

Analytical Method

Measurement of Pentoxifylline Release from Various Formulations

[0061] Approximately 15 cm of SpectraPor regenerated cellulose dialysis tubing (6000-8000 molecular weight cut off, cat. #132650, Source: Spectrum Medical Industries, Inc.) is rinsed in distilled water to remove preservatives. One end is sealed with the appropriate sized closure.

[0062] 5 ml of the formulation to be tested was placed in the tubing and the other end sealed as close as possible to the sample. The tubing is placed in a beaker containing 95 ml of phosphate buffer (0.05 M KH.sub.2PO.sub.4+0.0391 M NaOH, pH 7.4) and a magnetic stirring bar. The solution was mixed on low speed at room temperature. One ml samples were withdrawn (via pipet) at each time point and diluted to an appropriate volume (either 10 or 25 ml) with water for UV absorbance measurements.

[0063] UV absorbance of the test solution is determined at 273 nm versus a water blank. A 100% release standard is prepared by diluting 5 ml o...

example 4

Surgical Trial on Prospective Study on Adhesions in the Rabbit Model

[0066] To assess the potential of poloxamer 407 with pentoxifylline to prevent or reduce adhesions, the following experiment was performed.

[0067] The following solution of of 14% poloxamer 407 with 1.2% pentoxifylline was prepared:

3 Ingredient Percent by Weight Poloxamer 407, NF 14.00 Pentoxifylline 1.20 Tromethamine (TRIS), USP 0.1091 Maleic Acid 0.1045 Sodium Hydroxide pellets, USP 0.0420 Sodium Chloride, USP 0.04 Sterile Water for Irrigation, USP 82.54

[0068] Water was weighed into a tared vessel. Pentoxifylline, tromethamine, maleic acid and sodium hydroxide were added to the water and mixed for twenty minutes. The pH and osmolality of the solution were tested and found to be 7.6 and 109 mOsm / Kg, respectively. The solution was cooled to 6.degree. C. and the poloxamer was added to the solution over a two-hour period with constant stirring. The solution was stored under a nitrogen atmosphere at 4.degree. C. for fif...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Fractionaaaaaaaaaa
Percent by massaaaaaaaaaa
Fractionaaaaaaaaaa
Login to View More

Abstract

A method and compositions for reducing post-surgical adhesion formation / reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.

Description

[0001] This application is a continuation of application Ser. No. 09 / 516,640, filed Mar. 1, 2000, which is a continuation of application Ser. No. 09 / 141,122, filed Aug. 27, 1998, now U.S. Pat. No. 6,034,088, which is a continuation of application Ser. No. 08 / 540,229, filed Oct. 6, 1995, now U.S. Pat. No. 5,843,470.[0002] This invention relates to methods and compositions for inhibiting post-surgical adhesions in the mammalian abdominal or thoracic cavity or other body spaces, whether accidentally or surgically created.DESCRIPTION OF THE RELATED ART[0003] There is a need for improved methods and compositions for inhibiting adhesion formation / reformation in body spaces of mammals, whether accidentally or surgically created. According to Ellis in a review entitled, "The Cause and Prevention of Post-operative Intraperitoneal Adhesions," in Surgery, Gynecology and Obstetrics for September 1971, volume 133, pages 497-509, at pages 502-503, the prevention of adhesions has been the subject ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/04A61L31/06A61L31/16C08G65/26
CPCA61L31/041Y10S514/95A61L31/16A61L2300/204A61L2300/424A61L2300/802C08G65/2609A61L31/06Y10S514/822Y10S514/885Y10S514/975C08L71/02C08L89/06C08L5/08C08L5/04C08L5/00C08L1/28
Inventor REEVE, LORRAINE E.FLORE, STEPHEN G.
Owner REEVE LORRAINE E
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com