A superfine powdered Chinese medicinal composition and preparation method thereof

A technology of ultrafine powder and composition, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of increased surface energy, unclear active ingredients, inaccurate doses, etc., to avoid inherent defects and improve bioavailability. The effect of simplifying the formulation process

Inactive Publication Date: 2007-07-11
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. Bezoar and musk are animal medicinal materials, and frankincense and myrrh are resinous medicinal materials. The active ingredients in the medicine are not clear, and it is reasonable to use medicinal powder as medicine. However, due to the large particle size of the resin medicinal materials, the pills are not easy to disintegrate, causing biological The utilization rate is not high, and the medicinal materials are wasted
[0005] 2. The technical content of the drug is low, the dosage of the medicinal material is large, and the price of the traditional Chinese medicinal material is relatively expensive, which brings difficulties to the popularization and application of this product
[0013] Although the research on ultrafine pulverization of traditional Chinese medicine has become an upsurge, there are some problems or problems with practical application significance that have not been effectively solved. These problems or problems include: decrease, the energy required for further pulverization continues to increase, and when the particle size reaches a certain level, the pulverization efficiency is significantly reduced (2) Even after the pulverization is completed, it is still easy to cause: the surface energy increases, Make the particles in an unstable state; poor fluidity, easy to aggregate to form false large particles; increased wettability, easy to absorb moisture; increased adsorption, easy to absorb impurities in the air
(3) Due to the existence of the above problems, technical problems such as poor powder fluidity, inaccurate dosage, easy moisture absorption, and difficult molding of tablets occurred in the preparation process of traditional Chinese medicine micropowder, which seriously affected the practical application of traditional Chinese medicine micropowder and became a traditional Chinese medicine. The bottleneck of superfine pulverization technology or the connection between Chinese medicine superfine powder and Chinese medicine preparation
[0015] Therefore, there is no real ultrafine powder Chinese medicine, and there is no real industrially feasible ultrafine pulverization method.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] Prescription: Bezoar 10g Musk 85g

[0117] Frankincense 400g Myrrh 600g

[0118] Preparation method: take the above-mentioned medicinal materials, dry, clean, mix, conventionally crush through a 40-mesh sieve, add 0.2 times the amount of micro-powder silica gel as a dispersant, and use a vibrating mill for ultra-fine grinding at low temperature for 45 minutes to obtain ultra-fine grains with a central particle size of less than 10 μm. The mixture is poured into pills with water, and placed in a ventilated and dry place to dry in the shade to obtain superfine pellets.

Embodiment 2

[0120] Prescription: Bezoar 20g Musk 10g

[0121] Frankincense 600g Myrrh 400g

[0122] Preparation method: Take the above-mentioned medicinal materials, dry, clean, mix, conventionally pulverize through an 80-mesh sieve, add 0.2 times the amount of micro-powder silica gel as a dispersant, and use a vibrating mill for ultra-fine pulverization at low temperature for 20 minutes to obtain ultra-fine grains with a central particle size of less than 10 μm. The mixture is packed into capsules to obtain supermicrocapsules.

Embodiment 3

[0124] Prescription: Bezoar 10g Musk 10g

[0125] Frankincense 550g Myrrh 600g

[0126] Preparation method: Take the above medicinal materials, dry, clean, mix, conventionally crush through a 20-mesh sieve, add 0.5 times the amount of glyceryl capricate as a matrix, and use a vibrating mill to ultrafinely pulverize at low temperature for 30 minutes to obtain a central particle size of less than 10 μm The ultrafine mixture of the mixture is packed into soft capsules to obtain ultramicron capsules.

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Abstract

The invention relates to a Chinese drug composite, especially a micro powder, wherein it is formed by calculus bovis, moschus to be prepared into mastic, myrrh, etc. And it can treat influx and cancer, etc. The invention also provides relative production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition using superfine powder of traditional Chinese medicine as a raw material, and belongs to the field of traditional Chinese medicine. At the same time, it also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] 1. Basis for topic selection of Xihuang preparation [0003] "The Ministry of Health of the People's Republic of China Ministry of Health Standards" The Chinese patent medicine species recorded in the ninth volume of the preparation of traditional Chinese medicine - Xihuang Wan, which is composed of four herbs of bezoar, musk, frankincense (made), and myrrh (made) (of which Myrrh (preparation) is the preparation of myrrh, frankincense (preparation) is the preparation of frankincense), and similar preparations include Xihuang Capsules (recorded in the 17th volum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/328A61K9/107A61K9/14A61K9/16A61K9/20A61K9/48A61P35/00A61P17/00A61K35/55A61K9/00A61K35/413
Inventor 高淑英
Owner 北京凯瑞创新医药科技有限公司
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