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Dripping pills of folium alstoniae scholaris and its preparation process

A technology of Dengtaiye and Yedropping Pills, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve the problems of affecting the full effect of the medicine, low bioavailability, and long disintegration time limit, etc., to achieve Good for labor protection and environmental protection, high bioavailability, good for GMP management

Inactive Publication Date: 2007-07-04
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablet preparation technology, such oral preparations have long disintegration time, poor absorption, slow onset of action, and low bioavailability, which affect the full play of drug efficacy.
At the same time, it is easy to split, change color, absorb moisture, etc. during storage, and the quality is unstable
Granules are easy to absorb moisture, the amount of excipients is large, and the dosage is large and inconvenient

Method used

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  • Dripping pills of folium alstoniae scholaris and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Take 2000g of the leaves of the lampstand leaf, add water to decoct twice, add 10 times the amount of water for the first time, and 7 times the amount for the second time, decoct for 1 hour each time, combine the filtrate, filter, and concentrate the filtrate to a relative The density is 1.30 (20°C); add ethanol to make the alcohol content 65%, stir evenly, let it stand for 24 hours, take the supernatant to recover ethanol, concentrate it into extract, and dry the extract in vacuum to obtain the extract. Get the extract, pulverize it, and pass through a 100-mesh sieve, and the ratio by weight is the extract of the leaf of the lampstand: polyethylene glycol 6000 = 1:3 ratio, add to the melted base (88°C), stir evenly, drop into simethicone coolant (2°C), separate drop pills, absorb the coolant, dry to obtain.

Embodiment 2

[0018] Embodiment two: get the extract of embodiment one, pulverize, cross 100 mesh sieves, by weight be the root extract of bean root: the ratio of mixed matrix=1: 2 (mixed matrix is ​​Polyethylene Glycol 6000 : poloxamer according to 1:0.2 formula), add to the melted mixed matrix (85°C), stir evenly, drop into the simethicone coolant (4°C), separate the dropping pills, absorb the coolant , dried, that is.

Embodiment 3

[0019] Example 3: In this example, the roundness, pill weight difference, hardness, dissolution time and other indicators are investigated through the formulation of the extract of the lampstand leaf and different matrixes, so as to determine the weight ratio of the extract to a single or mixed matrix.

[0020] Trials of the extracts of the leaves of the lampstand and different matrix formulations (extracts are 1 part)

[0021]

[0022] 9

Polyethylene glycol 6000: carboxymethyl starch

Sodium = 1:0.3 (5 parts)

+++

＜10

+++

＜10

+++

10

Polyethylene glycol 6000: Poloxamer

=1:0.2 (1 part)

+++

＜10

+++

＜10

+++

11

Polyethylene glycol 6000: Poloxamer

=1:0.2 (5 parts)

+++

＜10

+++

＜10

+++

[0023] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the heat preservation t...

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PUM

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Abstract

The invention belongs to the field of pharmaceutical medicine, specifically relates to a drug lamp stand leaves pills and its preparation method which has effect of relieving cough, removing the phlegm and anti-inflammatory and applies to chronic bronchitis and pertussis. The invention use extracts from the herbal material lamp stand leaves and is prepared by lamp stand leaves extract and pill base. The bioavailability of the invention is high, the drug stability is good, drug size is small, taking and carry is easy, in particular is help for patient swallow medication who has swallowing difficulty. It has the characteristics of rapid collapse and dissolution, high dissolution degree, rapid releasing medication, rapid effect and so on, and production technology is simple and cost is low.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Dengtaiye dripping pill and a preparation process thereof. Background technique [0002] Chronic bronchitis is a common and frequently-occurring disease that seriously endangers the health of the people, especially in the elderly, and up to about 15% of patients over 50 years old. Serious complications: obstructive emphysema, bronchopneumonia, bronchiectasis. And can lead to deterioration of respiratory function, respiratory failure. Not only does it bring pain to the patient, but it also affects the patient's ability to work and take care of themselves, and when it develops into complications, it can endanger the life of the patient. [0003] Among the traditional Chinese medicines in our country, ethnic medicine is a wonderful flower, and Dai medicine is one of the four major ethnic medicines. Dai medicines are mostly made of local ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/24A61K9/20A61P11/00A61K127/00
Inventor 陈茜滕慧丽
Owner 陈茜
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