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Eriobotuya japonica extract, and composition containing same and use

A loquat flower and extract technology, which is applied in the field of extract prepared from loquat flower as a raw material medicine, can solve the problems such as complex and complicated efficacy of loquat flower and no effective quality control, and achieve a simple, easy and reproducible quality control method. Good, wide range of effects

Active Publication Date: 2007-06-13
CHENGDU QINGSHAN LIKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex composition of traditional Chinese medicine, the reported loquat flowers are mostly used in compound preparations, and can be used as food alone, and because the efficacy of loquat flowers is complex, there is no relevant report that can effectively control its quality and fully reflect the quality of its medicinal effects

Method used

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  • Eriobotuya japonica extract, and composition containing same and use
  • Eriobotuya japonica extract, and composition containing same and use
  • Eriobotuya japonica extract, and composition containing same and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]The preparation of embodiment 1 loquat flower extract of the present invention

[0029] Weigh 500g loquat flower sample, put it in a 5000ml round bottom flask, add ten times the amount of 75% ethanol, reflux at 70°C for 2h, and collect the reflux liquid. The residue was then condensed and refluxed with five times the volume of 75% ethanol for 2 h, and the two extracts were combined. The extract is packed into a flask, and on a rotary evaporator, the temperature of the water bath is 50° C., and the speed is 95 rpm, and it is spin-dried into a loquat flower extract extract.

Embodiment 2

[0030] Embodiment 2 The determination test of extraction solvent of the present invention

[0031] (1) Determination of solvent

[0032] Accurately weigh a certain amount of loquat flowers, add methanol, ethyl acetate, 95%, 75%, 50% ethanol and 100ml of water as solvents, reflux for 2.5h, rotary steam, constant volume in a 100ml volumetric flask, and determine the total flavonoids and the content of oleanolic acid and ursolic acid to obtain the best extraction solvent.

[0033] solvent

[0034] To sum up, the content of total flavonoids in the water extract was the highest. Based on the total content of total flavonoids, ursolic acid and oleanolic acid, the content extracted with 75% ethanol is the highest. Therefore, the solvent selected for extraction of the extract of the present invention is preferably 75% ethanol.

[0035] (2) Take a certain amount of loquat flower sample, add solvent 75% ethanol according to the following orthogonal table, reflux extraction, ...

Embodiment 3

[0038] Embodiment 3 loquat flower extract HPLC fingerprint spectrum determination method of the present invention

[0039] The fingerprints of loquat flowers were determined by HPLC. Experiment with RP-C 18 The chromatographic column was used as the stationary phase, methanol-buffer was used as the mobile phase for linear gradient elution, and the pH of the buffer was adjusted to 3.4 with acetic acid. Gradient elution program: the ratio of methanol and buffer (pH=3.4) solution in 0-5min is 30:70 for 0-5min; 50:50 for 5-6min; 50:50 for 6-16min; 50:50 for 16-26min It was 94:6; 26~46min became 100:0; 46~70min was 100:0, the flow rate was 0.5mL / min, and the ultraviolet detection wavelength was 210nm.

[0040] The specific experimental method is:

[0041] 1. Instruments, reagents and materials

[0042] 1.1 Instrument

[0043] 1) U.S. DIONEX high performance liquid chromatography [SOR-100 Solvent Rack, P680 HPLC Pump, ASI-100 Automated Sample Injector, PDA-100 Photodiode Array ...

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Abstract

The present invention relates to an eriobotrya japonica lindl flower extract. It is made up by using flower, alabastrum and receptacle of eriobotrya japonica lindl as raw material and adding water or organic solvent through a certain extraction process, in which the total flavone content is 50-350 mg / g. Besides, said invention also provides its preparation method and application. Said extraction has the functions of relieving cough and inhibiting bacteria.

Description

technical field [0001] The invention relates to a loquat flower extract, in particular, it is an extract prepared from loquat flower as a raw material medicine, and belongs to the field of medicine. Background technique [0002] Loquat (Eriobotrya japonica Lindl), also known as Luju, Jinwan, Luju, Luzhi, etc., belongs to Rosaceae (Rosaceae). Producing countries, the cultivated area and output account for more than 2 / 3 of the world. Mainly distributed in the provinces south of the Yangtze River. Among them, the three major production areas are Putian in Fujian, Tangqi in Zhejiang, and Dongting Mountain in Jiangsu. Other provinces such as Sichuan, Anhui, Guizhou, Hunan, Hubei, Guangdong, Guangxi, Yunnan, Hainan, and Taiwan are all cultivated. Its leaves, flowers, roots and fruits can be used medicinally. [0003] The most important medicinal part of loquat is the leaf. The use of loquat leaf in medicine was first recorded in "Famous Doctors", and it was listed as a Chinese ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P11/14A61P31/04G01N30/02A61K133/00
Inventor 张宏张晓喻陶宗娅许禄昙
Owner CHENGDU QINGSHAN LIKANG PHARMA CO LTD
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