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Preparation method of polyethylene imine nanometer gelatin

A polyethyleneimine and nanogel technology is applied in the preparation of polyethyleneimine nanogels, the preparation of nanometer drug carriers and nanogene carriers, and can solve the problem of toxic residues affecting the biocompatibility of nanogels, Difficult to obtain pulsed high-energy electrons, low solid content of nanogels, etc., to achieve the effects of excellent storage stability and dispersion, pure nanogels, and green synthesis process

Inactive Publication Date: 2007-04-25
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The second is to use acrylates as monomers and cross-linking agents, and use reverse-phase microemulsion polymerization technology to obtain polycationic gene carrier nanogels with uniform particle size distribution and a particle size of 40 to 200 nanometers. The preparation of nanogels by this emulsification process requires the use of a large amount of initiators and surfactants. These toxic chemicals are extremely difficult to remove after the reaction is completed, and the existence of toxic residues seriously affects the biocompatibility of nanogels. sex
However, the pulsed high-energy electrons used in this method are difficult to obtain, the solid content of the obtained nanogel is extremely low, the preparation efficiency is low, and the preparation cost is high.

Method used

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  • Preparation method of polyethylene imine nanometer gelatin
  • Preparation method of polyethylene imine nanometer gelatin
  • Preparation method of polyethylene imine nanometer gelatin

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Take 5mL of polyethyleneimine aqueous solution with a concentration of 1g / L and a molecular weight of 600 in the reactor, deoxidize, and quickly add 3.7mL of FeCl with a concentration of 2.5g / L and a pH of 1 to 3 2 The solution was stirred and reacted at room temperature for 1 day, and unreacted reactants were removed. The particle diameter of the product measured by dynamic light scattering was 48nm, the polydispersity coefficient was 0.17, and the Zeta potential was 32mV.

Embodiment 2

[0038] Take 5mL of polyethyleneimine aqueous solution with a concentration of 6.4g / L and a molecular weight of 1200 in the reactor, deoxidize, and quickly add 2.5mL of FeCl with a concentration of 2.5g / L and a pH of 1 to 3 2 The solution was stirred at room temperature for 1 day to remove unreacted reactants. The particle diameter of the product measured by dynamic light scattering was 71nm, the polydispersity coefficient was 0.13, and the Zeta potential was 33mV (accompanying drawing 3).

Embodiment 3

[0040] Take 8mL of polyethyleneimine aqueous solution with a concentration of 6.4g / L and a molecular weight of 2000 in the reactor, deoxidize, and quickly add 1.58mL of FeCl with a concentration of 7.2g / L and a pH of 1 to 3 2 The solution was stirred at room temperature for 1 day to remove unreacted reactants. The particle diameter of the product measured by dynamic light scattering was 30nm, the polydispersity coefficient was 0.27, and the Zeta potential was 32mV (accompanying drawing 4).

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Abstract

The invention discloses a preparing method of polyethylene imine nanometer gel, which comprises the following steps: placing polyethylene imine solution in the reacting bottle; deoxidizing; adding metal ionic solution according to different proportions rapidly; purifying after reacting; removing residual polyethylene imine nanometer gel. The Zeta potential is higher than +32mV with narrow grain size distribution, which is controllable between 30 and 80nm.

Description

technical field [0001] The invention relates to a preparation method of a nano drug carrier and a nano gene carrier, in particular to a preparation method of polyethyleneimine nano gel, which belongs to the technical field of nano biomedicine. Background technique [0002] Nanogel can be used as a drug or gene transduction carrier, and its composition is mainly water-filled polymer, which is similar to the composition and mechanical properties of human soft tissue, and has good biocompatibility; moreover, the high hydration of nanogel It can overcome the defects that ordinary hydrophobic nanoparticles are easy to be cleared non-selectively by the reticuloendothelial system, easy to adsorb proteins in blood, and generate precipitation when coupled with hydrophobic drugs. Therefore, the research on the synthesis method of polymer nanogels has become a frontier and hot research issue in the field of international nanobiomedicine in recent years. [0003] At present, there are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L39/02A61K47/32
Inventor 余家会张淑彦罗淑芳刘顺英俞磊
Owner EAST CHINA NORMAL UNIV
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