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Gambir plant extract and its use in preparation of target organ protective medicine

The technology of extract and urticol alcohol is applied in the field of urticol alcohol extract and its new use in the preparation of target organ protection drugs, which can solve the dysfunction of arteriole vasomotion, abnormal contraction of blood supply arterioles, and target organ deficiency. Blood damage and other problems, to achieve the effect of inhibiting the proliferation of renal fibroblasts, reducing the area, and inhibiting glomerular fibrosis

Inactive Publication Date: 2007-04-04
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. The diastolic function of the arterioles in the target organ is disordered, which leads to abnormal contraction of the blood supply arterioles in the organ, which reduces the blood flow of the organ and causes ischemic damage to the target organ
4. The primary disease causes oxidative stress, which releases a large amount of oxygen free radicals in the body and causes damage to target organs
[0003] Since the target organ damage caused by hypertension and diabetes is caused by a variety of independent risk factors, most of the current chemically synthesized drugs are designed for one of the pathways of action, so often only partial curative effects can be obtained

Method used

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  • Gambir plant extract and its use in preparation of target organ protective medicine
  • Gambir plant extract and its use in preparation of target organ protective medicine
  • Gambir plant extract and its use in preparation of target organ protective medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 prepares uncaria alcohol extract

[0029] 1) Take 10 kg of genuine Uncaria, crush it, add 80% ethanol, heat and extract 5 times, filter, and combine the filtrates;

[0030] 2) Concentrate the filtrate under reduced pressure into a thick extract, add 0.5% hydrochloric acid to dissolve, wash, and collect the filtrate;

[0031] 3) The filtrate is extracted with chloroform, and the filtrate is adjusted to pH 8 with an alkaline solution, and the chloroform solution is combined after several times;

[0032] 4) Concentrate the chloroform solution under reduced pressure to obtain the rhycarpa alcohol extract. Embodiment 2, the pharmacological action experiment of Rhycarpa alcohol extract

Embodiment 2

[0032] 4) Concentrate the chloroform solution under reduced pressure to obtain the rhycarpa alcohol extract. Embodiment 2, the pharmacological action experiment of Rhycarpa alcohol extract

[0033] (1) Anti-myocardial injury caused by ischemia-reperfusion, and reduce the size of myocardial infarction.

[0034] experimental method

[0035] Ninety Wistar rats with a body weight of 250 to 300 grams were randomly divided into the following 3 groups and given drugs / solvents by gavage:

[0036] 1. Sham operation group: Vegetable oil (1 ml / kg body weight) was given once a day.

[0037] 2. Ischemia-reperfusion group: Vegetable oil (1 ml / kg body weight) was given once a day.

[0038] 3. Ischemia-reperfusion + uncaria alcohol extract group: once a day, give vegetable oil suspension of uncaria alcohol extract (dose 100 mg / kg body weight; suspension concentration: 100 mg / ml).

[0039] The rats in the 3 groups were given drugs or solvents once a day according to the above scheme, and t...

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PUM

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Abstract

An application of the alcohol extract of urcaria stem with hooks in preparing the medicines for the target protection to organs, such as heart, kidney, etc, to prevent and treat cardiac failure and renal failure is disclosed.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine rhycarpa alcohol extract and its new application in medicine, in particular to an uncaria alcohol extract and its new application in preparing target organ protection medicines. Background technique [0002] Target organ damage is the root cause of disability and death in patients with systemic diseases such as hypertension and diabetes. Target organ damage often involves vital organs such as the heart and kidneys. The mechanism of its occurrence includes multiple independent pathways of action. For example: 1. Hyperplasia and hypertrophy of the walls of small blood vessels in target organs, the main reason of which is the hyperplasia of vascular smooth muscle cells induced by primary diseases such as hypertension and diabetes. In the heart, it manifests as narrowing of the coronary artery lumen, and the blood flow decreases, causing myo...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P9/10A61P13/12A61P39/06A61P43/00
Inventor 朱依纯朱依谆姚泰
Owner FUDAN UNIV
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