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Medicinal composition and its preparing method

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve lipid drugs such as niacin, pravastatin, lovastatin; thrombolytic drugs such as warfarin, heparin, urokinase, Streptokinase, insignificant tonic effect, low bioavailability and other problems, to achieve the effect of increasing the number of cell divisions, improving the quality of life, and strong physiological activity

Inactive Publication Date: 2007-03-28
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, western medicines such as nitroglycerin, nitrate preparations such as nitroglycerin, sorbitol mononitrate, etc. for the treatment of coronary heart disease; Proprolol, pindolol, metoprolol; calcium channel blockers such as verapamil, nifedipine, diltiazem; antiplatelet drugs such as aspirin, dipyridamole, besulfazone; Blood lipid adjustment drugs such as niacin, pravastatin, and lovastatin; thrombolytic drugs such as warfarin, heparin, urokinase, and streptokinase; however, during the course of medication, it was found that these drugs can relieve acute symptoms, but they are not yet effective for the cause However, traditional Chinese medicines such as Compound Danshen Dripping Pills, Compound Danshen Tablets, Suxiao Jiuxin Pills, Shexiang Baoxin Pills, etc. have shown certain advantages, but most of them have low bioavailability and low efficacy. Slow, complex formula, large dosage and other disadvantages
In the prior art, Chinese invention patent 93103012.9, titled "a Chinese patent medicine for treating angina pectoris of coronary heart disease" and patent application number 01131789.2, titled "a kind of traditional Chinese medicine for treating coronary heart disease and its law enforcement", both use ginsenoside as medicine, Although it has a certain effect on relieving symptoms, the tonic effect is not obvious, and it is not suitable for improving the overall function of the human body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] Example 1: 10 parts of ginseng, 0.1 part of total glycosides of paeony

[0117] Take the ginseng medicinal material, add 8 times the volume of 70% ethanol to reflux and extract 3 times, each time for 1 hour, combine the extracts, recover the ethanol under reduced pressure to 60°C, measure the relative density to 1.05-1.15, add 4 times the volume of the medicinal material in water to dissolve, Filter, the filtrate passes through ZTC-1 type macroporous adsorption resin at a speed of 0.5ml / g medicinal material.min, wash impurities with 7 times of resin volume water and 5 times of resin volume 10% ethanol successively, and then use 60% of 5 times of resin volume Desorb with ethanol, collect the desorbed liquid, recover the ethanol under reduced pressure to 60°C, measure the relative density to 1.05-1.15, and dry it to obtain ginseng extract; mix the ginseng extract and total glucosides of paeony evenly, add water for injection, stir to dissolve, and boil Finally, add 0.5% (...

Embodiment 2

[0118] Example 2: 3000 parts of ginseng and 1 part of total glucosides of paeony

[0119] Take the ginseng medicinal material, add 6 times the volume of 60% ethanol to reflux and extract twice, each time for 2.5 hours, combine the extracts, recover the ethanol under reduced pressure to 60°C, measure the relative density to 1.05-1.15, add 5 times the volume of the medicinal material in water to dissolve, Filter, the filtrate passes through ZTC-1 type macroporous adsorption resin at a speed of 0.5ml / g medicinal material.min, wash impurities with water 7 times the volume of the resin and 10% ethanol 4 times the volume of the resin successively, and then use 60% of the volume 4 times the volume of the resin Desorb with ethanol, collect the desorbed liquid, recover the ethanol under reduced pressure to 60°C, measure the relative density to 1.05-1.15, and dry to obtain ginseng extract; add water for injection and stir to dissolve, boil, adjust the pH value to between 5.0-7.0, The me...

Embodiment 3

[0120] Embodiment 3: 10000 parts of ginseng, 50 parts of total glycosides of paeony

[0121]Take the ginseng medicinal material, add 10 times the volume of 80% ethanol to reflux and extract twice, each time for 2.0 hours, combine the extracts, recover the ethanol under reduced pressure and measure the relative density to 1.05-1.15 at 60°C, add 3 times the volume of the medicinal material in water to dissolve, Filtrate, the filtrate passes through ZTC-1 type macroporous adsorption resin at a speed of 0.3-0.8ml / g medicinal material min, wash impurities with water 5 times the volume of the resin and 8% ethanol 3 times the volume of the resin in turn, and then use 4 times the volume of the resin Desorb with 70% ethanol, collect the desorption liquid, recover the ethanol under reduced pressure to 60°C, measure the relative density to 1.05-1.15, and dry to obtain the ginseng extract; add water for injection to dissolve, adjust the pH value between 5.0-7.0, and prepare the liquid for ...

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PUM

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Abstract

The present invention relates to a medicine composition for curing angiocardiopathy and cerebrovascular diseases and its preparation method. The prescription of said medicine composition is formed from ginseng (or ginseng stem and leaf portion or red ginseng or pilose asiabell root) or its extract and red peony total glucoside or white peony total glucoside. Said medicine composition can be made into injection preparation and oral preparation.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, and provides a preparation method of the composition, which belongs to the technical field of medicines. technical background [0002] Cardiovascular and cerebrovascular diseases are the first major diseases that seriously threaten human life and health today, and have become the first and second causes of death in most countries in the world. It not only has a high fatality rate, but also leads to disability of patients after its onset The rate is also very high. At present, 2.6 million people die from cardiovascular and cerebrovascular diseases in my country every year, and one person dies from such diseases every 12 seconds, among which coronary heart disease ranks first. It is reported that coronary heart disease has become an important disease that threatens the lives and health of the public. It is estimated that more than 1 million pe...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/14A61K9/16A61K9/20A61K9/48A61P9/10A61K31/704
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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