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Medicine for preventing and treating senile dementia and its prepn and use

A technology for Alzheimer's disease and medicine, which is applied to the total flavonoids of Epimedium and its preparations, the application in health care products, and the field of medicine, can solve problems such as unsatisfactory effect, unsatisfactory long-term efficacy, toxic and side effects, etc. Effects of monoamine neurotransmitter metabolism, controllable drug quality, and improving memory impairment

Inactive Publication Date: 2007-03-21
南京宇道科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although countries around the world have invested a lot of money in the research and development of drugs for the treatment of Alzheimer's disease, the effect is not very satisfactory
Most varieties have a certain therapeutic effect and can improve the cognitive function of patients in the short term, but the long-term efficacy and side effects are not optimistic

Method used

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  • Medicine for preventing and treating senile dementia and its prepn and use
  • Medicine for preventing and treating senile dementia and its prepn and use
  • Medicine for preventing and treating senile dementia and its prepn and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation technology of embodiment 1 epimedium total flavonoids (refined by extraction method)

[0040] Wash and dry the Chinese herbal medicine Epimedium, add 10 times the amount of 75% ethanol after coarse powder, reflux extraction, extraction time 1.5 hours, filter, add 8 times the amount of 70% ethanol to the medicinal material, reflux extraction twice, the second The first extraction time is 1 hour, the second extraction time is 0.5 hours, filter, combine the three reflux extracts, discard the medicinal residues; concentrate the combined solution under reduced pressure until there is no ethanol smell, and recover ethanol; add 1 / 3 volumes of ethyl acetate as an organic solvent, mix well and let stand, separate the extraction layer and the water layer; add 1 / 4 volume and 1 / 5 volume of ethyl acetate to the water layer in turn and extract twice, and separate the water layer , combined the extract layers obtained three times, concentrated under reduced pressure, ...

Embodiment 2

[0042] The preparation technology of embodiment 2 epimedium total flavonoids (macroporous resin column separation and purification);

[0043] Wash and dry the Chinese herbal medicine Epimedium, add 10 times the amount of 75% ethanol after coarse powder, reflux extraction, extraction time 1.5 hours, filter, add 8 times the amount of 70% ethanol to the medicinal material, reflux extraction twice, the second The first extraction time is 1 hour, the second extraction time is 0.5 hours, filter, combine the three reflux extracts, discard the medicinal residues; concentrate the combined solution under reduced pressure until there is no ethanol smell, and recover ethanol; the concentrated solution passes through the macroporous adsorption resin Column, eluted with water until the eluent is colorless, and then eluted with 70% ethanol solution, collected the ethanol eluate, concentrated under reduced pressure, and recovered ethanol; put the obtained extract in a vacuum drying oven, at 60...

Embodiment 3

[0045] Embodiment 3 oral tablet

[0046] Epimedium total flavonoids 0.05~0.40g / tablet

[0047] Magnesium stearate 0.1-0.3 mg / tablet

[0048] Sodium carboxymethyl starch 4~12 mg / tablet

[0049] Microcrystalline cellulose 50-100mg / tablet

[0050] Mix the total flavonoids of Epimedium with sodium carboxymethyl starch and microcrystalline cellulose, sieve, mix well, add an appropriate amount of water or ethanol of appropriate concentration to granulate, after drying, granulate, add an appropriate amount of stearin Magnesium acid, the granules are then compressed into tablets using a punch of appropriate diameter.

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Abstract

The present invention is one kind of medicine for preventing and treating senile dementia and its preparation and use. The medicine has epimedium as the single ingredient, which is treated through solvent extraction, macroporous resin elution, drying and other technological steps to obtain epimedium total flavone used as the main component. The medicine is used in preventing and treating vascular dementia, Alzheimer disease and other senile dementia. It may be prepared into tablet, capsule, soft capsule, granule, dripping pill and other preparation forms.

Description

Technical field: [0001] The invention relates to a medicine for preventing and treating senile dementia and its preparation and use, in particular to the use of total flavonoids of Epimedium and its preparations extracted from traditional Chinese medicinal material Epimedium in the preparation of medicines for preventing and treating senile dementia, health care application in products. Background technique: [0002] Alzheimer's disease is a primary degenerative disease of the central nervous system, with a slow onset and a chronic course, with an average of 5 to 10 years, characterized by comprehensive progressive dementia. Its main clinical phase is dementia syndrome, which mainly manifests as high-level neural activity disorders such as memory, language, judgment, cognition, thinking, behavior, personality, and emotion, accompanied by aphasia, apraxia, agnosia, agraphia, and dyslexia. Alzheimer's disease can be divided into Alzheimer's dementia, cerebrovascular dementia,...

Claims

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Application Information

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IPC IPC(8): A61K36/296A61K31/7048A61K31/352A61K9/08A61K9/107A61K9/12A61K9/16A61K9/20A61K9/48A61K9/02A61P25/28
Inventor 阮锦满史美耿石海云王永毅姚小燕
Owner 南京宇道科技开发有限公司
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