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Medicines of different characters and their prepn and use

A technology of traits and medicines, applied in the field of medicine, can solve the problems of calcium dibutyrylcyclic adenosine phosphate hydrate and anhydrate that have not been reported in the literature, and achieve the effect of changing functions

Inactive Publication Date: 2007-03-21
刘力 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It is reported in the literature that the acidity range of the national standard [WS~10001~(HD~0786)~2002] of calcium butyrylcyclic adenosine monophosphate containing 2.3 crystal waters is 3.0~5.0. So far, there is no published literature report and the above-mentioned properties. Different calcium dibutyryl cyclic adenosine monophosphate hydrates and anhydrates

Method used

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  • Medicines of different characters and their prepn and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 In a dry three-necked flask, add 6.5g of cAMP triethylamine salt, 8.5ml of anhydrous pyridine, 33ml of double-distilled butyric anhydride, 200ml of chloroform, and keep stirring at 20-70°C to dissolve all the sponge, and react After the solvent is evaporated under reduced pressure, slowly add distilled water to complete the reaction at low temperature, then concentrate under reduced pressure to form a slurry, which is dbeAMP; take dibutyryl cyclic adenosine phosphate (dbeAMP) slurry and dissolve it in ethanol, add Add an appropriate amount of calcium chloride in ethanol and acetone aqueous solution, stir, mix thoroughly, dry the solvent under reduced pressure, rinse with anhydrous ether and acetone, and dry, add absolute ethanol and refined acetone to mix, add no Diethyl ether in water, placed, filtered, the solid was rinsed with anhydrous ether, drained, and dried under reduced pressure at 50-80°C for 72 hours in the presence of phosphorus pentoxide to obtain ...

Embodiment 2

[0042] Example 2 In a dry three-necked flask, add 6.5g of cAMP triethylamine salt, 8.5ml of anhydrous pyridine, 33ml of double-distilled butyric anhydride, 220ml of chloroform, and stir continuously at 28-55°C to dissolve the sponge-like substance completely, and react After the solvent is evaporated under reduced pressure, slowly add distilled water to complete the reaction at low temperature, then concentrate under reduced pressure to form a slurry, which is dbeAMP; take dibutyryl cyclic adenosine phosphate (dbeAMP) slurry and dissolve it in ethanol, add Add an appropriate amount of calcium chloride in ethanol and acetone aqueous solution, stir, mix thoroughly, dry the solvent under reduced pressure, rinse with anhydrous ether and acetone, and dry, add absolute ethanol and refined acetone to mix, add no Diethyl ether in water, set aside, filtered, the solid was rinsed with anhydrous ether, drained, and dried under reduced pressure for 30 hours to obtain off-white powder. Mel...

Embodiment 3

[0047] Example 3 In a dry three-necked flask, add 6.5g of cAMP triethylamine salt, 8.6ml of anhydrous pyridine, 35ml of double-distilled butyric anhydride, 200ml of chloroform, and keep stirring at 20-70°C to dissolve the sponge-like substance completely. After the solvent is evaporated under reduced pressure, slowly add distilled water to complete the reaction at low temperature, then concentrate under reduced pressure to form a slurry, which is dbeAMP; take dibutyryl cyclic adenosine phosphate (dbeAMP) slurry and dissolve it in ethanol, add Add an appropriate amount of calcium chloride in ethanol and acetone aqueous solution, stir, mix thoroughly, dry the solvent under reduced pressure, rinse with anhydrous ether and acetone, and dry, add absolute ethanol and refined acetone to mix, add no Diethyl ether in water, set aside, filtered, the solid was rinsed with anhydrous ether, drained, and dried under reduced pressure for 12 hours to obtain a light yellow powder. Slightly sol...

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Abstract

The present invention is dibutyrul adenosine cyclophosphate calcium and its hydrate in the molecular formula of C18H23N5O8P.1 / 2Ca.nH2O, where n=0-2 5 of different characters. Dibutyrul adenosine cyclophosphate calcium is slightly soluble in water at room temperature and insoluble in ethanol and has high storage stability. Dibutyrul adenosine cyclophosphate calcium and its hydrate are used as protein kinase activator for treating cardiac and cerebral vascular diseases mainly as well as in regulating growth of mammals.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to provide a dibutyryl cyclic adenosine monophosphate calcium hydrate and anhydrate with different properties and its preparation and application. Background technique [0002] The literature "Complete Works of Contemporary Structural Drugs" reported that N 6 -2'-O-dibutyryl 3', 5'-cyclic adenosine monophosphate calcium salt dihydrate, but its name is dibutyryl cyclic adenosine monophosphate (Bucladesine), the Chinese chemical name and the English chemical name are two Butyryl cyclic adenosine monophosphate, one-to-one correspondence can better reflect the problem is that its CA registration number [362-74-3] is actually dibutyryl cyclic adenosine monophosphate, which only mentions the dihydrate with calcium salt, but No description of any properties is given; the national drug standard [WS~10001~(HD~0786)~2002] stipulates that the hydrate of calcium dibutyry...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K9/14A61K9/19A61P9/00A61P9/02A61P9/04A61P9/06A61P9/10A61P17/06A61P29/00A61P35/00A61P7/02A61P11/00A61P1/16A61P43/00
CPCA61K9/19A61K31/7076A61P1/16A61P9/00A61P9/02A61P9/04A61P9/06A61P9/10A61P11/00A61P17/06A61P43/00
Inventor 刘力陈祺吴志刚戴静刘珍李玲
Owner 刘力
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