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Normal temperature and sub-normal temperature in vitro heart preserving perfusate

A preservation solution and sub-normal temperature technology, which is applied in the preservation, application, and animal husbandry of human or animal bodies. It can solve the problems of no heart preservation solution, reduce anti-host reactions, increase survival rate, and cause less damage to the heart.

Inactive Publication Date: 2007-03-21
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, there is no heart preservation solution under normal temperature and subnormal temperature conditions.

Method used

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Experimental program
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Effect test

Embodiment Construction

[0042] Element

[0043] Preparation method: take part of distilled water, and electrolyte (NaCL, KCL, NaH 2 PO 4 ·H 2 O, MgSO 4 , NaHCO 3 ) was first added therein, then heparin was added, then amino acids and plasma proteins were added, finally red blood cells were added, and finally the total volume was adjusted to 1 liter with distilled water.

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PUM

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Abstract

The normal temperature and sub-normal temperature in vitro heart preserving perfusate as one kind of organ preserving matter consists of basic electrolyte, energy matter and protecting matter. Each liter of the heart preserving perfusate contains NaCl 5.0-7.0 g, KCl 0.3-0.5 g, NaH2PO4 .H2O 100-150 mg, MgSO4 50-100 mg, NaHCO3 3.0-5.0 g, L-argine 70-100 mg, histidine 30-60 mg, L-cystine 50-70 mg, L-methionine 10-50 mg, levo glutamine 500-700 mg, L-lysine 100-170 mg, glycine 10-50 mg, L-isoleucine 70-150 mg, L-serine 30-50 mg, L-leucine 70-150 mg, L-tryptophane 10-20 mg, L-tyramine 80-150 mg, L-valine 70-150 mg, L-threonine 80-150 mg, choline chloride 3-8 mg, vitamin B2 0.5-3 mg, pantothenic acid 3-g mg, folic acid 3-8 mg, pyridoxal 3-10 mg, nicotinamide 3-10 mg, etc. The present invention has the effects of preserving in vitro heart efficiency, reducing rejection reaction of organ and prolonging the survival period of organ.

Description

technical field [0001] The invention relates to an isolated heart perfusion preservation solution, which belongs to a heart preservation substance under the condition of normal temperature and subnormal temperature. Background technique [0002] Currently, the effective time limit for the preservation of organs to be transplanted is relatively short, and the clinical preservation time of isolated hearts generally does not exceed 5 hours. Under this current situation, it is difficult to carry out long-distance transportation of isolated hearts, which limits the long-distance deployment of hearts to be transplanted and causes a certain amount of waste. In addition, due to the short storage time, there is not enough time to find a patient with a good match. The heart resources are either discarded or barely transplanted to the patient, which reduces the quality of the transplant and the long-term survival rate of the heart after transplantation. This is also a waste to some ext...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
Inventor 王贵波吴军罗高兴黄赤兵卞修武
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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