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Process for increasing cryptotanshinone content in Danshen extract

A technology of cryptotanshinone and extract, which is applied in the field of treatment and extraction of salvia miltiorrhiza, to achieve the effect of simple method, extremely low cost, and easy industrialized large-scale production

Inactive Publication Date: 2007-03-14
庚朋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In the existing methods for extracting Salvia miltiorrhiza, the content of cryptotanshinone in the final extract usually only reaches about 10%

Method used

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  • Process for increasing cryptotanshinone content in Danshen extract
  • Process for increasing cryptotanshinone content in Danshen extract
  • Process for increasing cryptotanshinone content in Danshen extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 20 kg of freshly harvested Salvia roots that are 2 years old, wash the soil, cut off the reeds, cut into thin slices with a thickness of about 0.5 cm with a medicine cutter, dry, pass a 10-mesh sieve, and save the dander to obtain 12 kg of dried decoction pieces.

[0033] Put the above-mentioned decoction pieces into the Soxhlet extractor, place the dander on the top, add 70L of 95% ethanol to immerse the decoction pieces, heat to 50°C for 3 hours, heat up to 90°C, reflux and extract for 3 hours, and control the flow rate of the extract , So that the ethanol solution is always immersed in the decoction pieces, and the reflux is stopped when the extract is nearly colorless, and all the extract is released.

[0034] Under stirring, add 20% sodium hydroxide solution to the above extract to make its pH=10, stop stirring, stand for 4 hours for precipitation, filter to remove the precipitate, add 10% hydrochloric acid dropwise to the filtrate to make the solution pH=7.

[00...

Embodiment 2

[0041]Take 15kg of dried Danshen roots, wash the soil with clean water, cut off the reed heads, cut into thin slices with a thickness of about 0.3cm with a medicine cutter, dry, pass through a 10-mesh sieve, and save the dander to obtain 12kg of dried decoction pieces.

[0042] Put the above-mentioned decoction pieces into the Soxhlet extractor, place the dander on the top, add 70L of 95% ethanol, heat to 50°C, keep it for 3 hours, slowly put it into the evaporator, and stop dispensing when the ethanol has just passed the decoction pieces The evaporator is heated to 90°C for reflux extraction, adjust the outflow rate of the extract and the evaporation volume of the evaporator, keep the ethanol solution always immersed in the decoction pieces, reflux for about 3 hours, stop refluxing when the extract is nearly colorless, and release all the extract .

[0043] Under stirring, add 20% sodium hydroxide solution to the above extract to make its pH=9, stop stirring, stand still for 4 ho...

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Abstract

The invention discloses a method to increase the content of cryptotanshinone in salvia miltiorrhiza extract, the method includes the following steps: Salvia miltiorrhiza is extracted with ethanol solution by recirculation percolating and salvia miltiorrhiza ethanol extracts is obtained; remove tannins in the obtained extracts, salvia miltiorrhiza ethanol extracts with tanning removal is got, the obtained salvia miltiorrhiza ethanol extracts with tanning removal is recovered once, second recovery is done after the first one, After the second reduction, o salvia miltiorrhiza ethanol extracts is oxidized. The salvia miltiorrhiza (total) ketone content of the products got using the invention method and its cryptotanshinone content is significantly higher than that of the product using existing technology approaches, the method will create tremendous economic benefits, moreover the requirement of the variety of salvia miltiorrhiza is unstrict, and the method is simple.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine extraction and processing method, in particular to an extraction and processing method of Salvia miltiorrhiza. The method significantly increases the cryptotanshinone content in the extract of Salvia miltiorrhiza. Background technique [0002] Danshen is a traditional Chinese medicine. With the development and improvement of extraction and separation technology, the pharmacological effects of salvia miltiorrhiza extract and its various components have gradually become clear. Salvia miltiorrhiza can be extracted with organic solvents, such as alcohols, ethers, etc. The extract contains a variety of effective ingredients, among which the fat-soluble components are collectively called salvia (total) ketones, which are basically phenanthrenequinone substances with bactericidal and antibacterial functions. It includes the following ten monomer components, cryptotanshinone, dihydrotanshinone I, hydroxytanshi...

Claims

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Application Information

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IPC IPC(8): A61K36/537C07D307/77
Inventor 庚朋
Owner 庚朋
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