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Process for increasing cryptotanshinone content in Danshen extract

A technology of cryptotanshinone and extract, which is applied in the field of treatment and extraction of salvia miltiorrhiza, to achieve the effect of extremely low cost, loose variety requirements and simple method

Inactive Publication Date: 2009-09-23
庚朋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In the existing methods for extracting Salvia miltiorrhiza, the content of cryptotanshinone in the final extract usually only reaches about 10%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 20 kg of freshly harvested salvia miltiorrhiza roots, wash the soil, cut off the reed head, cut into thin slices with a thickness of about 0.5 cm with a medicine cutter, dry them in the sun, pass through a 10-mesh sieve, and retain the skin scraps to obtain 12 kg of dried decoction pieces.

[0033] Put the above decoction pieces into the Soxhlet extractor, put the skin flakes on the top, add 70L95% ethanol to immerse the decoction pieces, heat to 50°C, keep warm for 3 hours, heat up to 90°C and reflux for 3 hours to control the outflow speed of the extract, Make the ethanol solution submerge the decoction pieces all the time, stop the reflux when the extract is nearly colorless, and release all the extract.

[0034] Under the condition of stirring, add 20% sodium hydroxide solution to the above-mentioned extract to make it pH=10, stop stirring, let stand still for 4 hours to precipitate, filter to remove the precipitate, and add 10% hydrochloric acid dropwise to the...

Embodiment 2

[0041] Take 15 kg of dried Salvia miltiorrhiza roots, wash the soil with water, cut off the reed head, cut into thin slices with a thickness of about 0.3 cm with a medicine cutter, dry them in the sun, pass through a 10-mesh sieve, and retain the skin scraps to obtain 12 kg of dried decoction pieces.

[0042] Put the above decoction pieces into the Soxhlet extractor, put the dander on the top, add 70L of 95% ethanol, heat to 50°C, keep it warm for 3 hours, slowly put it into the evaporator, stop draining when the ethanol just submerges the decoction pieces, Heat the evaporator to 90°C for reflux extraction, adjust the outflow speed of the extract and the evaporation capacity of the evaporator, keep the ethanol solution submerged in the decoction pieces all the time, reflux for about 3 hours, stop the reflux when the extract is nearly colorless, and release all the extract.

[0043] Under the condition of stirring, add 20% sodium hydroxide solution to the above-mentioned extract...

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PUM

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Abstract

The invention discloses a method to increase the content of cryptotanshinone in salvia miltiorrhiza extract, the method includes the following steps: Salvia miltiorrhiza is extracted with ethanol solution by recirculation percolating and salvia miltiorrhiza ethanol extracts is obtained; remove tannins in the obtained extracts, salvia miltiorrhiza ethanol extracts with tanning removal is got, the obtained salvia miltiorrhiza ethanol extracts with tanning removal is recovered once, second recovery is done after the first one, After the second reduction, o salvia miltiorrhiza ethanol extracts is oxidized. The salvia miltiorrhiza (total) ketone content of the products got using the invention method and its cryptotanshinone content is significantly higher than that of the product using existing technology approaches, the method will create tremendous economic benefits, moreover the requirement of the variety of salvia miltiorrhiza is unstrict, and the method is simple.

Description

technical field [0001] The invention relates to a method for extracting and processing traditional Chinese medicines, in particular to a method for extracting and processing salvia miltiorrhiza. The method can significantly increase the content of cryptotanshinone in the salvia miltiorrhiza extract. Background technique [0002] Danshen is a traditional Chinese medicinal herb. With the development and improvement of extraction and separation techniques, the pharmacological effects of Danshen extract and its various components have gradually become clear. Salvia miltiorrhiza can be extracted with organic solvents, such as alcohol, ether, etc., and its extract contains a variety of active ingredients. Including the following ten monomer components, cryptotanshinone, dihydrotanshinone I, hydroxytanshinone IIA, tanshinone IIB, methyl tanshinate, tanshinone IIA, danshenxinquinone, danshenxinquinone A, danshenxinquinone B, and danshenxinquinone C. The antibacterial ability of sa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537C07D307/77
Inventor 庚朋
Owner 庚朋
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