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Novel use of 2(2-hydroxypropyl) phenol

A technology of hydroxypropyl and phenol, which is applied in the new application field of 2(2-hydroxypropyl)phenol, can solve the problems of short drug duration and other problems, and achieve the effect of simple preparation method, broad application prospect and stable chemical structure

Inactive Publication Date: 2007-03-14
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the long-term production of medicines, it was found that after the application of o-allylphenol, although the bactericidal spectrum is broad and the disease prevention effect is remarkable, the duration of the medicine is short, and multiple applications are required to achieve good control effects.

Method used

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  • Novel use of 2(2-hydroxypropyl) phenol
  • Novel use of 2(2-hydroxypropyl) phenol
  • Novel use of 2(2-hydroxypropyl) phenol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The preparation of embodiment 1,2 (2-hydroxypropyl) phenol

[0011] 2(2-hydroxypropyl)phenol can be synthesized from allylphenol, and the reaction formula is as follows:

[0012]

[0013] A 250mL three-necked flask was equipped with a thermometer, a reflux condenser and a constant pressure dropping funnel, and 13.4g (0.1mol) of 96% o-allylphenol and 20mL of ethyl acetate were added to the three-necked flask, and a magnetic stir bar was added. Add 50mL of 50% sulfuric acid into the separatory funnel, start the electromagnetic stirrer, add sulfuric acid dropwise to the reaction bottle under cooling in an ice bath, remove from the ice bath after the dropwise addition, and stir at room temperature for 1 h.

[0014] The synthesized product was separated and purified by column chromatography (filler was silica gel), and detected by mass spectrometry, the molecular ion peak was 150.9, and the ion fragment peaks were 107.1 and 93.3, respectively. The mass spectrum is shown i...

Embodiment 2

[0017] The biological activity of embodiment 2,2 (2-hydroxypropyl) phenol

[0018] Effect of 2(2-hydroxypropyl)phenol on wheat sheath blight (Rhizoctonia cerealis), melon and fruit rot fungus (Rhizoctonia cerealis), tomato gray mold (Botrytis cinerea) and apple rot fungus (Valsa mali) by growth rate method The above strains were all selected from commonly used commercial strains.

[0019] Figure 2-Figure 5 are photos of the inhibitory effect of different concentrations of 2 (2-hydroxypropyl) phenol on Rhizoctonia acerealis (concentrations are respectively 0, 5, 10, 25, 50, 100 μg·mL -1 ); apple rot pathogen (Valsa mali) (concentrations were 0, 10, 25, 50, 100, 200 μg·mL -1 ); tomato gray mold (Botrytiscinerea) (concentrations were 0, 5, 10, 25, 50, 75 μg·mL -1 ); wheat sheath blight (Rhizoctonia cerealis) (concentrations were 0, 1, 5, 10, 25, 50 μg·mL -1 ).

[0020] The antibacterial rate was calculated according to the following formula:

[0021]

[0022] Convert the ...

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Abstract

The invention discloses the new uses of 2 (2-hydroxypropyl) phenols. It is proved by the inventor of the invention through experiments that the 2(2-hydroxypropyl) phenol has a good antibacterial activity with a broad bactericidal spectrum, has distinguished inhibition ratio against various of pathogenic bacteria such as rhizoctonia solani on wheat, mildew germs on fruits, gray mold infection of tomato, and apples rot bacteria, and can be widely used for preparation of bactericidal agent.

Description

technical field [0001] The invention relates to a new application of 2(2-hydroxypropyl)phenol, in particular to the application of 2(2-hydroxypropyl)phenol as a fungicide. Background technique [0002] For a long time, people have been concerned about the safety of pesticides and their impact on the environment and ecology. Looking back at the various pesticides developed in the past, although they have various structures, the common point is that they all have a prototype structure, that is, a lead compound. Generally, there are three approaches for the discovery of lead compounds: random screening, imitation of existing agrochemicals, natural products and their metabolites, and structure-based molecular design. Biomimetic synthesis is the technical route of searching for new active lead compounds or new targets from natural active substances and their metabolites, and developing new pesticides through analogous synthesis or biological rational design. [0003] O-allylphe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N31/08A01P3/00
Inventor 李健强曲田丽曹永松刘西莉
Owner CHINA AGRI UNIV
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