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Calcium sulfate semihydrate group combined self-curing bio-active material, preparation and application thereof

A calcium sulfate hemihydrate, bioactive technology, applied in the field of human hard tissue defect filling repair materials, human bone and tooth defect filling and repairing bioactive materials, can solve the lack of long-term structural support, poor injectability of bone cement paste, Metabolism and other issues, to achieve excellent biological activity and biocompatibility, excellent biological performance, and simple preparation process

Inactive Publication Date: 2007-03-07
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some defects in the application of this material, which are mainly reflected in the following aspects: First, although this material solidifies quickly and can provide structural support for the defect site in a short time, the bone cement paste can Poor injectability and lack of ability to provide long-term structural support to the repair site; secondly, although this material has good biocompatibility and osteoconductivity, it is not bioactive and does not promote bone regeneration
Third, clinical studies have shown that this material degrades too quickly in the body, which easily leads to a large amount of fluid leakage from the repair site, and a large amount of SO released during the degradation process 4 2- , in addition, this material also has the problem of metabolism

Method used

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  • Calcium sulfate semihydrate group combined self-curing bio-active material, preparation and application thereof
  • Calcium sulfate semihydrate group combined self-curing bio-active material, preparation and application thereof
  • Calcium sulfate semihydrate group combined self-curing bio-active material, preparation and application thereof

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Experimental program
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Effect test

Embodiment 1

[0041] 1) Blending liquid preparation

[0042] Weigh 1.0 g of analytically pure sodium bicarbonate and dissolve it in 99.0 mL of deionized water to obtain a 1.0% sodium bicarbonate solution, sterilize, seal it in a sterile bottle, and set aside.

[0043] 2) Preparation of β-calcium sulfate hemihydrate / tricalcium silicate composite bone defect filling material:

[0044] The β-calcium sulfate hemihydrate / tricalcium silicate composite material powder with a tricalcium silicate content of 20wt.% and the blending solution are fully blended at a ratio of liquid-solid mass ratio of 1.0:1 for 0.5-1 minute, and injected into the mold. Cured at 37°C and 100% humidity for more than 7 days (see Figure 1 for the XRD figure), and then the mold was released to obtain the β-calcium sulfate hemihydrate / tricalcium silicate composite pellets ( CSH / C 3 Spellets). The compressive strength of the pellets can reach 7.0-9.0 MPa, and the degradation rate can reach over 90% after 21 days, while havi...

Embodiment 2

[0046] 1) Blending liquid preparation

[0047] Weigh 1.0 g of analytically pure sodium bicarbonate and dissolve it in 99.0 mL of deionized water to obtain a 1.0% sodium bicarbonate solution, sterilize, seal it in a sterile bottle, and set aside.

[0048] 2) Preparation of β-calcium sulfate hemihydrate / tricalcium silicate composite self-curing material:

[0049] Fully blend the β-calcium sulfate hemihydrate / tricalcium silicate composite material powder with a tricalcium silicate content of 40wt.% and the blending solution at a ratio of liquid-solid mass ratio of 1.0:1 for 0.5-1 minute to obtain a usable β-calcium sulfate hemihydrate / tricalcium silicate composite self-curing material for minimally invasive treatment. The self-curing material can reach the initial setting in about 18 minutes after being injected into the defect site, the self-curing material slurry can be injected within 15 minutes, the compressive strength of the self-curing material can reach 10.0-12.0MPa, and...

Embodiment 3

[0051] 1) Blending liquid preparation

[0052] Weigh 1.0 g of analytically pure sodium bicarbonate and dissolve it in 99.0 mL of deionized water to obtain a 1.0% sodium bicarbonate solution, sterilize, seal it in a sterile bottle, and set aside.

[0053] 2) Preparation of β-calcium sulfate hemihydrate / tricalcium silicate composite degradable material

[0054] The β-calcium sulfate hemihydrate / tricalcium silicate composite material powder with a tricalcium silicate content of 30wt.% and the blending solution are fully blended for 0.5-1 minute according to the ratio of liquid-solid mass ratio of 0.8:1, according to the embodiment 1, the β-calcium sulfate hemihydrate / tricalcium silicate composite particle used for bone defect repair materials can be obtained, the compressive strength can reach 10.0-12MPa, and the degradation rate can reach more than 90% after 21 days; The tricalcium acid content is 30wt.% β-calcium sulfate hemihydrate / tricalcium silicate composite material powde...

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Abstract

The invention relates to a self-solidification biological active material of hemigydrate calcium sulfate base, relative production and application. Wherein, the invention is characterized in that: said material is paste formed by harmony liquid, hemigydrate calcium sulfate / tricalcium silicate composite powder, while their mass ratio is 0.8-1.2:1; said harmony liquid is one of deionized water, analogue humor, inorganic salt solution or inorganic solution; the content of tricalcium silicate in the hemigydrate calcium sulfate / tricalcium silicate composite is 1-50%. The invention can be shaped freely, without cell toxicity, while it can be degraded stepped with adjustable speed, and it can induce the generation of skeleton agustite, with higher activity then calcium sulfate material.

Description

technical field [0001] The invention relates to a calcium sulfate hemihydrate-based composite self-curing bioactive material, its preparation and its application. More precisely, the invention relates to a human body hard tissue defect filling and repairing material, that is, as a biological material for filling and repairing human bone and tooth defects. Active materials, uses in orthopedics, dentistry and minimally invasive treatments. It belongs to the field of medical biomaterials. Background technique [0002] Calcium sulfate cement (Calcium Sulfate Cements, CSCs) has been used as a bone defect filling material for more than 100 years, and its earliest related research can be traced back to 1892 (Henry et al., Clinical Pharmaco-kinetics 1995; 29:36-45). β-calcium sulfate hemihydrate (CaSO 4 1 / 2H 2 O, Calcium Sulfate Hemihydrate, CSH) is calcium sulfate dihydrate (CaSO 4 2H 2 O, Calcium Sulfate Dihydrate, CSD) is a flaky crystal obtained by heating and dehydrating ...

Claims

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Application Information

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IPC IPC(8): A61L27/46
Inventor 常江郇志广
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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