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Application of ketanserin in preparing medicine for preventing cerebral apoplexy

A kind of technology of ketanserin and stroke, applied in the field of medicine

Inactive Publication Date: 2007-03-07
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Kenserin is a drug used to treat high blood pressure and can improve reflex function, but so far there are no reports about the use of ketanserin to prevent stroke and prolong life

Method used

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  • Application of ketanserin in preparing medicine for preventing cerebral apoplexy
  • Application of ketanserin in preparing medicine for preventing cerebral apoplexy
  • Application of ketanserin in preparing medicine for preventing cerebral apoplexy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: The predictive effect of systolic blood pressure (SBP) and BRS on the occurrence of SHR-SP stroke:

[0015] Eighty-two SHR-SP rats aged about 7 months, both male and female, were used. Femoral artery and femoral vein were intubated under anesthesia, fed, connected to a computerized conscious self-management system after 2 days of recovery, stabilized for 4 hours, recorded blood pressure, measured BRS, and then continued to feed, recorded the time of stroke occurrence and survival after surgery , rats that died within 15 days after operation were not included in the record range. Ended at 400 days postoperatively. Almost all of the animals eventually died of stroke.

[0016] We divided the rats into two groups according to the size of BRS: low BRS-L group (BRS0.3ms / mmHg, n=34). too much difference. The postoperative survival curves of the two groups were significantly different (Log-Rank test x 2 value 8.06, P=0.0045), the postoperative median death time ...

Embodiment 2

[0020] Example 2: Effects of single gastric tube administration of ketanserin on SBP, diastolic blood pressure (DBP) and BRS of SHR-SP

[0021] Twelve 8-month-old male SHR-SP rats were intubated in the femoral artery, femoral vein and stomach under anesthesia, fed, and connected to a computerized conscious self-management system after 2 days of recovery, stabilized for 4 hours, and continuously recorded blood pressure for 1 hour , Determination of BRS. Then the animals were divided into two groups, 0.3 mg / kg and 3.0 mg / kg of ketanserin were given by gastric tube respectively, the blood pressure was recorded continuously for 1 hour, and then the BRS was measured. The results are shown in Table 1. The low-dose ketanserin group (0.3mg / kg) had no significant effect on blood pressure (SBP: 228±25.6 vs 232±22.3mmHg; DBP: 163±18.9 vs 165±19.1mmHg, P>0.05), and the high-dose (3.0mg / kg) can significantly reduce blood pressure (SBP: 199±15.9 vs 232±24.1mmHg; DBP: 133±16.5 vs 162±25.6...

Embodiment 3

[0024] Embodiment 3: the influence of long-term administration of ketanserin (3 months) on SHR-SP hemodynamics

[0025] 29 5-month-old male SHR-SP were randomly divided into 3 groups: control group (n=9), ketanserin low-dose group (0.3mg / kg / d, n=10) and high-dose group (3.0mg / kg / d, n=10), the drug was mixed into the feed for continuous administration, and the body weight change was recorded. After 4 months of administration, the blood pressure, cardiac interval (HP) and BRS were measured according to the method of Experiment 1. The results showed that: long-term administration of ketanserin, compared with the blank control group, the large and small dose groups had no significant effect on body weight, and the 0.3mg / kg ketanserin group had no significant effect on SBP (231±12.8 vs 231±25.7mmHg), DBP (166 ±14.5 vs 160±23.1mmHg) had no significant effect, while the 3.0mg / kg group could significantly reduce SBP (202±22.3 vs 231±25.7mmHg), DBP (144±17.4 vs 160±23.1mmHg); small, ...

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Abstract

The invention relates to a research on the prediction of artery pressure baroreflex sensitivity, BRS on dead brain, and the research of antihypertensive ketone selin on dead brain. Wherein, (1), BRS can be used as one independent factor to predict the occur of dead brain, that the occur time of BRS-high animal is later then the lower one; (2), ketone selin can effective improve BRS, without affected by its amount, to delay the dead brain and prolong life time.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to the application of ketanserin, a medicine for improving arterial baroreflex function, in the preparation of medicines for preventing stroke. Background technique [0002] The incidence rate of hypertension is high, as high as 18% in Chinese adults. At present, there are 160 million hypertensive patients in my country. Stroke is the most important complication of hypertension. Once a stroke occurs, the consequences will be serious, and the patient will either die or be disabled. There are 15 million new strokes every year in the world, of which 5 million die and 5 million are permanently disabled. Restoring survivors to function is time-consuming and labor-intensive. Therefore, when it comes to stroke, preventing it is more important than treating it. How to prevent the occurrence of stroke? In addition to lowering blood pressure, there are no other effective measures. Moreove...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/517A61P9/12A61P9/10
CPCA61K31/517A61P9/10A61P9/12
Inventor 苏定冯刘爱军于旭红吴明月
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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