Anti-cancer drugs slow release agent comprising anticancer antibiotics and synergist thereof
A technology of anticancer drugs and sustained-release preparations, which is applied in the field of sustained-release injections, sustained-release implants, compound anticancer drug sustained-release preparations, and can solve problems such as treatment failure and increased tolerance
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Embodiment 1
[0113] Put 90, 90, and 80 mg of polyphenylene propane (p-carboxyphenylpropane (p-CPP): sebacic acid (SA) at 20: 80) copolymers into 3 containers respectively, and add 100 ml of dichloromethane to each After dissolving and mixing, add medicine (10mg pemetrexed, 10mg doxorubicin, 10mg pemetrexed and 10mg doxorubicin), re-shake and use spray drying method to prepare 10% pemetrexed, 10% Doxorubicin, 10% pemetrexed and 10% doxorubicin injection microspheres, and then suspend the microspheres in physiological saline containing 15% mannitol to prepare the corresponding suspension sustained-release injection. The drug release time of the obtained slow-release injection in the physiological saline in vitro is 10-15 days, and the drug release time in the mouse subcutaneous is about 20-30 days.
Embodiment 2
[0115] The method step of being processed into sustained-release injection is the same as in Example 1, but the difference is that the contained anticancer active ingredients and their weight percentages are:
[0116] (a) 5-30% of bleomycin, daunomycin, doxorubicin, triiron doxorubicin, epirubicin, 7-O-methylnoga-4'-epirubicin, Diethoxyacetydoxorubicin, Mitomycin C, Actinomycin D, Nocardycin, Nocardioerythrin, Nocardycin, Nogamycin, Mitomycin, Polymycin Mycocin E, pilimycin, dirithromycin, antramycin, pelomycin, puromycin, spamycin, anthramycin, caraminomycin, puromycin, aromycin Bixing, Aclarubicin-B, Idarubicin, Serpentin, Clarithromycin, Adazol Hydrochloride, Adazol, Doxorubicin, Epirubicin, Valrubicin, pirarubicin, loxantrone, loxoxantrone, mitoxantrone, piroxantrone, tiloxantrone, or clozocin;
[0117] (b) 5-40% of 6-mercaptopurine, pemetrexed, disodium pemetrexed, lumitrexed, deoxyfluridine, fluoxuridine, mercaptopurine, thioguanine, carmofur, Tegafur, Zalcitabine, Em...
Embodiment 3
[0120] The method step of being processed into sustained-release injection is the same as in Example 1, but the difference is that the sustained-release auxiliary material used is polylactic acid (PLA), and its molecular weight peak value is 30000-50000; the contained anticancer active ingredient and its weight percentage are :
[0121] (a) 5-40% of 6-mercaptopurine, pemetrexed, disodium pemetrexed, lumitrexed, deoxyfluridine, fluoxuridine, mercaptopurine, thioguanine, carmofur, Tegafur, Zalcitabine, Emtricitabine, Gallocitabine, Ibacitabine, Ancitabine, Decitabine, Flucitabine, Enoxitabine, Mizotabine, Mitoquinone , mitotane, cytarabine, hydroxyurea, 5-fluorouridine, capecitabine, gemcitabine, fludarabine, raltitrezhan, raltitrexed, dexrazoxane, cladribine, nor latrexed or pentoside; or
[0122](b) 5-30% of bleomycin, daunorubicin, doxorubicin, triiron doxorubicin, epirubicin, 7-O-methylnoga-4'-epirubicin, Diethoxyacetydoxorubicin, Mitomycin C, Actinomycin D, Nocardycin, N...
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