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Liquid composition of sirolimus

A technology of liquid composition and sirolimus, which is applied in the field of pharmaceutical composition in liquid form, can solve the problems of low bioavailability, low bioavailability, inconvenient use, etc., achieve improved drug compliance and facilitate absorption , the effect of taking convenience

Inactive Publication Date: 2007-02-28
张建民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Secondly, the bioavailability of existing oral liquid is low, about 14%, as a kind of expensive raw material drug, low bioavailability may cause bigger loss; In addition, oral liquid (small plastic container packaging) uses It needs to be transferred out quantitatively, which is inconvenient to use

Method used

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  • Liquid composition of sirolimus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation of sirolimus liquid composition

[0041]Weigh 0.5 g of the sirolimus raw drug, add it into a container filled with 500 ml of propylene glycol solution, and stir until it is completely dissolved. Heat may be used to facilitate dissolution if necessary. Determination of content by HPLC method, that is, too.

Embodiment 2

[0043] Preparation of sirolimus liquid composition

[0044] Weigh 0.5g of sirolimus raw drug, add 150g of polyoxyethylene castor oil, mix evenly, add propylene glycol to 500ml, and stir until completely dissolved; it is also possible to first dissolve polyoxyethylene castor oil in propylene glycol solution, and then add Rolimus raw drug, stir until completely dissolved. Heat may be used to facilitate dissolution if necessary. Determination of content by HPLC method, that is, too.

Embodiment 3

[0046] Preparation of sirolimus liquid composition

[0047] Take 200g of polyoxyethylene castor oil, add propylene glycol to 500ml, stir until completely dissolved, then add 0.5g of sirolimus raw drug, stir until completely dissolved. Heat may be used to facilitate dissolution if necessary. Determination of content by HPLC method, that is, too.

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PUM

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Abstract

The invention discloses a liquid composition of immune inhibiting agent ciromos, which consists of soluble solution system with ciromos and pre-emulsifying condensed liquid system, wherein the ciromos can dissolve in the methyl glycol, PEG, surface activator and plant oil.

Description

technical field [0001] The invention relates to pharmaceutical preparation technology, in particular to a pharmaceutical composition in liquid form for treating immunosuppressant sirolimus. Background technique [0002] Sirolimus is a macrolide antiimmune antibiotic produced by Streptococcus, which was reported in 1977 in rat adjuvant arthritis and experimental allergic meningitis models In recent years, studies on sirolimus have proved that it is a powerful immunosuppressant. It not only has a significant effect on a variety of autoimmune abnormalities, but also has a significant effect on different types of organ transplant animal models. Shows significant anti-rejection activity. Its role is mainly to inhibit the response of T cells and T cell-dependent B cells to graft antigens. It has a unique mechanism of action. In recent years, the research on its mechanism of action has made great progress. [0003] Sirolimus inhibits the activation and proliferation of T lymphoc...

Claims

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Application Information

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IPC IPC(8): A61K31/436A61K47/34A61K47/10A61K9/48A61K9/08A61P37/06A61P31/04
CPCA61K31/436A61K9/08A61K47/10A61K47/46A61P31/04A61P37/06
Inventor 刘瑜玲张建民
Owner 张建民
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