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Medicinal composition, preparation method and quality control method

A composition and drug technology, applied in the direction of drug combination, testing drug preparation, drug formula, etc., can solve problems such as many contraindications, achieve high bioavailability, reduce adverse reactions, and overcome the effects of low bioavailability

Inactive Publication Date: 2007-02-21
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, kudzu root preparations such as puerarin injection, ozagrel tablets, and ozagrel injection have been widely used to treat cardiovascular and cerebrovascular diseases, but while puerarin injection is widely used clinically, adverse reactions such as skin The reports of reactions, hemolysis, drug fever, angioedema, etc. are also increasing day by day. Ozagrel has gastrointestinal reactions and allergic reactions, and there are many contraindications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: prepare Radix Puerariae extract: get 10 parts of Radix Puerariae (part is: kilogram or gram)

[0030] Pueraria pueraria powder, add 70% ethanol to reflux and extract 3 times, each time for 1.5 hours, let stand, filter with suction, combine the filtrate, recover ethanol from the ethanol solution under reduced pressure, concentrate to 1:2, add hydrochloric acid, adjust the pH value to 1-2 acid solution; pass through the resin column equipped with macroporous resin, use water as the cleaning solution, use 50% ethanol with a pH value of 1-2 as the eluent for elution, and check the eluent with TCL; add NaOH solution to adjust the pH value to 5 -6, Concentrate, add diatomaceous earth evenly, dry, and grind into fine powder; put in a Soxhlet extractor and extract with ethyl acetate for 8 hours to obtain ethyl acetate liquid; add 2% activated carbon to reflux for 30 minutes, decolorize and filter, and concentrate the filtrate That is, kudzu root extract.

Embodiment 2

[0031] Embodiment 2: prepare Radix Puerariae extract: 1000 parts of Radix Puerariae (kg or gram)

[0032] Take coarse powder of medicinal materials, put it in a reflux extractor, heat reflux with 80% ethanol as solvent for 30 minutes, extract the extract in an ultrasonic cleaner for 30 minutes, filter and discard the filter residue, and concentrate the filtrate to obtain the kudzu root extract.

Embodiment 3

[0033] Embodiment 3: prepare Radix Puerariae extract: Radix Puerariae 3000 parts (kg or gram)

[0034]Take kudzu root, add 10 times the amount of water to soak for 30 minutes, decoct for 25 minutes, centrifugally filter, add 6 times the amount of water to the dregs, decoct twice, decoct for 30 minutes each time, filter, combine the filtrate, and use 3 times the amount of the extract The n-butanol was extracted three times, the n-butanol extracts were combined, and the n-butanol was evaporated under reduced pressure to obtain the kudzu root extract.

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PUM

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Abstract

A composite medicine in the form of injection or orally taken medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, apoplexy sequelae, cerebral thrombus, etc, is prepared from pueraria root or its extract and ozagrel. Its preparing process and quality control method are also disclosed.

Description

technical field [0001] The invention provides a compound preparation for treating cardiovascular and cerebrovascular diseases, as well as a preparation method and a quality control method of the composition, belonging to the technical field of medicines. technical background [0002] Cardiovascular and cerebrovascular diseases, such as coronary heart disease, myocardial infarction, and thromboembolic cerebrovascular disease are a major chronic disease that threatens the healthy population of the world, and there is a gradual upward trend in recent years. The death rate of cardiovascular and cerebrovascular diseases is an important indicator to measure the quality of life of a country or region, residents, and health care. With the advent of a well-off life and changes in dietary patterns, residents' desire for longevity and healthy survival continues to increase. In order to prevent and control the occurrence of cardiovascular and cerebrovascular diseases, it has become a ma...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K9/00A61P9/10A61P7/02G01N33/15A61K31/4164
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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