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Novel prepn. of levomisole, and its new use

A technology of levamisole and pathways, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, respiratory diseases, etc., can solve problems such as poor treatment effect, and achieve the effect of relieving symptoms and relieving inflammatory symptoms

Inactive Publication Date: 2007-02-14
JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 3. If the general treatment effect is not good
So far, there have not been any reports or literature records on the use of levamisole in the treatment of chronic sinusitis and adenoid hypertrophy at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 levamisole hydrochloride nasal spray

[0022] In a 10,000-level environment, levamisole hydrochloride was dissolved in normal saline to prepare a 1 mg / ml solution, and geramine was added to make the concentration of geramine 0.02%. Fill this medicinal solution in a nasal cavity spray bottle, screw on the spray valve to obtain the levamisole hydrochloride nasal cavity spray.

Embodiment 2

[0023] The preparation of embodiment 2 levamisole phosphate nasal spray

[0024] In a 10,000-grade environment, levamisole phosphate was dissolved in physiological saline to prepare a 1 mg / ml solution, and geramine was added to make the concentration of geramine 0.02%. Fill this medicinal solution in a nasal cavity spray bottle, screw on the spray valve to obtain the levamisole phosphate nasal cavity spray.

Embodiment 3

[0025] The preparation of embodiment 3 levamisole hydrochloride nasal cavity aerosol

[0026] In a 10,000-level environment, levamisole hydrochloride was dissolved in normal saline to prepare a 1 mg / ml solution, and geramine was added to make the concentration of geramine 0.02%. Fill the medicinal solution into a nasal cavity aerosol bottle, add propellant, and install an aerosol valve to obtain levamisole hydrochloride nasal cavity aerosol.

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PUM

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Abstract

A levamisole in the form of spray, aerosol, powder spray and nasal drops for treating chronic nasosinusitis and adenoids is disclosed.

Description

technical field [0001] The invention relates to levamisole nasal drops, sprays, aerosols and powder sprays for treating chronic sinusitis and adenoid hypertrophy and their application in treatment. Background technique [0002] 1. Chronic sinusitis [0003] Chronic sinusitis generally refers to chronic suppurative sinusitis, which is a chronic suppurative inflammation of the sinus mucosa, among which chronic maxillary sinusitis is the most common, and often coexists with chronic ethmoid sinusitis, mostly because acute suppurative sinusitis has not been treated in a timely and reasonable manner Due to delay. Infection and allergic rhinitis are also the main reasons. In recent years, sinus drainage disorders caused by lesions of the nasal passage complex have attracted widespread attention, and therefore sinusitis surgery under functional nasal endoscope has been carried out. [0004] 1. The main symptoms are: purulent nasal discharge, nasal congestion, headache (often mani...

Claims

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Application Information

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IPC IPC(8): A61K31/429A61P11/02A61P11/04A61P43/00
Inventor 郑文婕王鹤尧
Owner JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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