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Poly propenoic acid/polypeptide grafted copolymer and its preparing method and use

A technology of graft copolymer and polyacrylic acid, which is applied in the field of polyacrylic acid/polypeptide graft copolymer and its preparation and application, can solve the problems of lack of pH responsiveness and achieve the effect of easy preparation

Inactive Publication Date: 2007-01-24
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former is prepared by the initiation of macromolecules in the hydrophilic segment, and the latter is prepared by transesterification, but both lack pH responsiveness (that is, they are not sensitive to changes in the pH value of the application environment)

Method used

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  • Poly propenoic acid/polypeptide grafted copolymer and its preparing method and use
  • Poly propenoic acid/polypeptide grafted copolymer and its preparing method and use
  • Poly propenoic acid/polypeptide grafted copolymer and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] With 10 grams of PAA and 41 grams of PBLG, after dissolving completely with 100 grams of DMF, add 2 grams of DCC, carry out amidation reaction at normal temperature for 3 days, obtain the PAA-PBLG graft copolymer of following structure, wherein: m=685, n=50, x=20.

[0024]

Embodiment 2

[0026] After 4 g of PAA and 19 g of PBLG were completely dissolved in 200 g of DMF, 1 g of Boc was added 2 O, carry out amidation reaction at room temperature (15°C-30°C) for 3 days to obtain a PAA-PBLG graft copolymer with the structure shown in Example 1, wherein: m=9320, n=500, x=30.

Embodiment 3

[0028] After 20 grams of PAA and 13 grams of PELG were completely dissolved in 200 grams of DMF, 0.2 grams of CBMIT was added, and the amidation reaction was carried out at room temperature (15°C to 30°C) for 3 days to obtain a PAA-PELG graft copolymer with the following structure , wherein: m=6940, n=10, x=200.

[0029]

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Abstract

The present invention relates to a kind of polyacrylic acid / polypeptide grafted copolymer in the first as shown and its preparation process and application. The preparation process includes the main steps of: the first setting polyacrylic acid, solvent and condensing agent in reactor; and the subsequent adding peptide homoplymer to react at 15-30 deg.c to obtain the target product. The copolymer of the present invention may be used as the nanometer level release controlling carrier of hydrophobic medicine. The present invention has the advantages of pH response of the copolymer, easy preparation and capacity of controlling the relative content of the hydrophilic chain segment and the hydrophobic chain segment of the copolymer precisely.

Description

technical field [0001] The invention relates to a graft copolymer of polyacrylic acid and polypeptide, its preparation method and application. Background technique [0002] Amphiphilic polypeptide copolymers, the nanomicelles formed by self-assembly have a narrow particle size distribution, and the numerous peptide bonds on the main chain are easily broken and degraded by proteases in vivo to generate non-toxic small molecules, which are widely used Copolymers for the preparation of nano drug carriers. [0003] The existing peptide copolymers used to prepare nano-drug carriers (drug-loaded micelles) are mainly amphiphilic peptide block copolymers and peptides with hydrophobic peptides as the main chain and hydrophilic segments as side chains. graft copolymer. The former is prepared by the initiation of macromolecules in the hydrophilic segment, and the latter is prepared by transesterification, but both lack pH responsiveness (that is, they are not sensitive to changes in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K47/42C08F120/06
Inventor 陈涛林嘉平朱健琦刘峰
Owner EAST CHINA UNIV OF SCI & TECH
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