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Organic metal complex and its prepn. composition and use

A technology of organometallic complexes, which is applied in the fields of pharmaceuticals and food, can solve the problems of poor stability and loss of ascorbic acid function, and achieve the effects of easy absorption, good health and enhanced efficacy

Inactive Publication Date: 2007-01-03
曾雄飞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, ascorbic acid is one of the most basic medicines, but its poor stability has always been a problem that plagues people. Although people have made many efforts, they have not been able to find a good solution, including Seib, P.A. disclosed in US-4,647,672 Ascorbyl triphosphate, AsPP, and subsequent extensive research has shown that the function of ascorbic acid involved in said invention has been substantially lost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment one. the preparation of ascorbate calcium stearate.

[0048] In a 250ml round bottom flask with heating and magnetic stirring (the same below), add 85ml of water, gradually add 10g of ascorbic acid, raise the temperature to 35°C under stirring, gradually add 52g of calcium carbonate, stir for 100min, then add 14g of stearic acid 80ml of ether solution, continued the reaction for 90min, removed the solvent and moisture, and finally obtained 24.1g of calcium ascorbate stearate, containing 33% ascorbic acid.

Embodiment 2

[0049] Embodiment two. the preparation of ascorbate zinc stearate.

[0050] Equipment is the same as embodiment one. In the round bottom flask, add 105ml of water, gradually add 15g of ascorbic acid, heat up to 45°C under stirring, add 60g of zinc oxide, stir for 80min, then add 50ml of chloroform solution containing 21g of stearic acid, continue the reaction for 75min, remove the solvent and water, Finally, 37.3 g of ascorbate zinc stearate was obtained, containing 31.5% of ascorbic acid.

Embodiment 3

[0051] Embodiment three. the preparation of lactic acid magnesium ascorbate.

[0052] Equipment is the same as embodiment one. Add 155ml of water to the round bottom flask, stir to raise the temperature to 35°C, add 9.5g of lactic acid, after the dissolution is complete, gradually add 4.2g of magnesium oxide, stir for 45min, then add 19g of ascorbic acid, and continue the reaction for 85min. The obtained product was tested as magnesium ascorbate lactate, containing 8.1% magnesium and 58% ascorbic acid.

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PUM

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Abstract

The present invention relates to organic metal complex and its preparation process, composition and use. By means of metal molecule coordination center, nutrient is made to combine with organic acid and other organic and / or inorganic compound containing functional radical, so as to raise the function, stability and absorbing bioavailability and strengthen functions, such as resisting function and stress-resisting function.

Description

technical field [0001] The invention relates to the field of pharmacy, and more specifically relates to a new class of organometallic complexes, compositions containing the metal complexes and their preparation methods. In addition, the present invention also relates to the application of the metal complex in the fields of pharmacy and food. Background technique [0002] The threat of drug residues and drug resistance to human health has been paid more and more attention by human beings. Research and development of nutrient medicine is a new way to solve this technical problem. As the first nutrient drug invented, amino acid iodine has obtained the invention patent right, and the patent numbers are CN-ZL-01114666.4 and CN-ZL-01811670.1 respectively. Amino acid iodine can efficiently kill pathogenic microorganisms, including viruses, pathogenic bacteria and trichomonas, etc., and it can solve many difficult problems that cannot be solved by classic drugs. For example, asco...

Claims

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Application Information

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IPC IPC(8): C07F1/08C07F1/10C07F3/02C07F3/04C07F3/00C07F7/30C07F5/00C07F7/00C07F9/00C07F9/08C07F11/00C07F15/00A61K31/28A61K31/555A61K31/661A61P3/02A23L1/29A23L1/30
Inventor 曾雄飞曾江
Owner 曾雄飞
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