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Biological material film with porous structure and its prepn

A technology of biomaterials and porous structures, applied in medical science, prostheses, etc., can solve the problems of membrane exposure, influence, lack of active induction of differentiation and growth promotion, etc.

Inactive Publication Date: 2007-01-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it cannot be degraded by itself in the body, a second operation is required to remove it. If it is kept in place, complications such as bacterial infection will occur, and it is easy to cause soft tissue flap cracking and early exposure of the membrane, which will affect the amount of new bone formation.
[0004] The common disadvantage of the above two types of biofilms is that they can only function as mechanical barriers and isolation but do not actively induce differentiation and promote growth. They usually need to be used in combination with autologous bone or other bone substitutes, and are prone to infection. , thus affecting and limiting its application

Method used

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  • Biological material film with porous structure and its prepn
  • Biological material film with porous structure and its prepn
  • Biological material film with porous structure and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Dissolve 10g of polyamide 66 in 100ml of ethanol at 70-80°C with stirring and the action of catalyst calcium chloride to obtain a film-forming liquid of polyamide 66. After the film-forming liquid is cooled to 30-40°C, dissolve about 1.5ml Pour the film-forming solution onto a glass plate with a diameter of 12 cm to spread freely to form a film, dry at 70°C, mark the front and back with a marker pen, soak and wash it with 200ml deionized water for several times, and check that there is no chloride ion in the eluent with 1M silver nitrate solution (each soaking time is greater than 30 minutes), and dried at 70°C to obtain the polyamide 66 porous biofilm of the present invention.

[0043] The prepared polyamide 66 membrane has a porous structure, and the pores are interconnected with each other. The average pore diameter is about 60-70 μm, and the structure is as follows: figure 1 shown. The thickness of the porous membrane was 0.1 mm as measured with a vernier caliper....

Embodiment 2

[0045]Dissolve 20g of polyamide 66 in 100ml of ethanol at 70-80°C with stirring and the action of catalyst calcium chloride to obtain a film-forming liquid of polyamide 66. After the film-forming liquid is cooled to 30-40°C, dissolve about 2.5ml Pour the film-forming solution onto a glass plate with a diameter of 12 cm and spin to form a film, dry at 60°C, mark the front and back with a marker pen, soak and wash it with 200ml deionized water for several times, and check that there is no chloride ion in the eluent with 1M silver nitrate solution (each soaking time is greater than 30 minutes), and dried at 70°C to obtain the polyamide 66 porous biofilm of the present invention.

[0046] The prepared polyamide 66 membrane has a porous structure, the pores communicate with each other, and the average pore diameter is about 50-70 μm. The thickness of the porous membrane was measured with a vernier caliper to be 0.2 mm.

Embodiment 3

[0048] Dissolve 10g of polyamide 6 in 100ml of ethanol at 70-80°C with stirring and the action of catalyst calcium chloride to prepare a film-forming solution of polyamide 6. After the film-forming solution is cooled to 30-40°C, dissolve about 2ml of The membrane solution was poured onto a glass plate with a diameter of 12 cm to spread freely to form a membrane, dried at 70°C, marked with a marker pen on the front and back sides, soaked and washed several times with 200ml deionized water, and tested for the absence of chloride ions in the eluent with 1M silver nitrate solution ( The soaking time is greater than 30 minutes each time), and dried at 70°C to obtain the polyamide 6 porous biofilm of the present invention.

[0049] The prepared polyamide 6 membrane has a porous structure, the pores communicate with each other, and the average pore diameter is about 60-70 μm. Measured with a vernier caliper, the thickness of the porous membrane was 0.12 mm.

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Abstract

The biological material film with porous structure is medical film of polyamide or composite polyamide / nanometer osteolith material with through pores in gradually changed sizes, and has one compact side with fine pores in diameters of 0.01-30 microns and the opposite loose side with large pores in diameters of 30-300 microns. During its preparation, solvent with high volatility is used as the dispersant, medical polyamide or composite polyamide / nanometer osteolith material is heated and stirred to form the filming liquid, and film is formed and washed with deionized water to obtain the biological film. The porous biological film has controllable porous structure, and excellent mechanical performance and biological performance, and may be used widely as medial separating film, medicine slow releasing film, tissue regeneration inducing film, etc.

Description

technical field [0001] The invention relates to a biomaterial film which can be used in the medical and health field and a preparation method thereof. Background technique [0002] Since the 1990s, the use of artificial biofilms to guide the regenerative healing of body tissues has become an international hot research topic. Bio-membrane technology (Barrier Membrane Technique, referred to as BMT) is a new clinical treatment technology that has attracted widespread attention in the medical field in recent years. The principle of guided bone tissue regeneration is to use the physical barrier function of the biofilm to isolate the bone defect area from the surrounding tissue, create a relatively closed tissue environment, prevent the fibrous knot tissue from growing into the bone defect area, and protect the wound area. Blocking, guiding or inducing functions can fully mobilize the repair and healing potential of the tissue itself, and finally enable the regeneration and recon...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56
Inventor 李玉宝李吉东左奕
Owner SICHUAN UNIV
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