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Oral disintegrant tablet of total arasaponin and its prepn

A technology of Panax notoginseng saponins and orally disintegrating tablets, which is applied in the field of traditional Chinese medicine, can solve problems such as ineffective quality control, inconvenient use of injections, and long onset time of tablets, and achieves improved quality standards, convenient taking, and disintegration short time effect

Inactive Publication Date: 2007-01-03
李斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The preparations currently on the market have problems such as long onset time of tablets and inconvenient use of injections. In addition, the quality standards are low, and the quality cannot be effectively controlled, which affects the full play of the drug effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 5.0g Panax notoginseng saponins, with 3g mannitol, 0.1g aspartame, 5.0g microcrystalline cellulose, 4.5g crospovidone, 1.6g sodium carboxymethyl starch, 1.5g talcum powder, 0.5g micropowder The silica gel was mixed evenly, and directly compressed into tablets to make 100 orally disintegrating tablets.

Embodiment 2

[0020] 2.5g Panax notoginseng saponins, 2.0g mannitol, 0.5g aspartame, 2.5g low-substituted hydroxypropylmethylcellulose, 2.0g sodium carboxymethyl starch, 2.0g crospovidone, 7.0g Microcrystalline cellulose, 1.5g of micropowder silica gel, and 0.1g of magnesium stearate are mixed, passed through an 80-mesh sieve, and pressed into 100 tablets.

Embodiment 3

[0022] Mix 5.0g Panax notoginseng saponins, 1.5g talc powder, 0.5g micro-powder silica gel, 10.5g microcrystalline cellulose, 5.0g crospovidone, 1.0g aspartame, and make soft material granulation with water , add 1g sodium carboxymethyl starch, 0.1g magnesium stearate, granulate, and compress 100 tablets.

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PUM

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Abstract

The present invention discloses oral disintegrant tablet of total arasaponin and its preparation process. The oral disintegrant tablet consists of total arasaponin 5 weight portions, disintegrant 5-10 weight portions, lubricant 1-5 weight portions, filler 5-15 weight portions and corrective 1-7 weight portions. The disintegrant consists of cross-linked polyvidone and carboxymethyl starch sodium in the weight ratio of 1 to 0.1-1, and the corrective consists of mannitol and aspartame in the weight ratio of 5 to 0.1-3. The oral disintegrant tablet is prepared through a direct tabletting process or through a wet pelletizing and tabletting process. The present invention has the functions of promoting blood circulation to disperse blood clots and dredging meridian, and is used in treating apoplexy, hemiplegia, chest arthralgia caused cardiodynia, etc.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine preparation, in particular to a preparation method of an orally disintegrating tablet containing Panax notoginseng saponins. Background technique [0002] Preparations containing total saponins of Panax notoginseng, currently available preparations include: tablets, capsules, granules, injections, which have the effects of promoting blood circulation and removing stasis, dredging channels and collaterals, and are mainly used to treat stroke hemiplegia caused by blood stasis in the brain, heart Chest pain caused by blood stasis; cerebral infarction, coronary heart disease and angina pectoris with the above symptoms, and central retinal vein occlusion is a blood stasis syndrome. [0003] The drug is mainly used to promote blood circulation and remove stasis, dredge the meridians and activate the collaterals, so it is often used to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K9/20A61P9/10
Inventor 李斌
Owner 李斌
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