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Method for preparing oral administered sustained-release peptide micro capsule

A technology of slow-release microcapsules and drugs, which is applied in the fields of pharmaceutical formulations, drug combinations, drug delivery, etc., to achieve good application prospects, mild reaction conditions, and good reproducibility

Inactive Publication Date: 2006-12-20
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In recent years, although some progress has been made in the study of non-injection drug delivery of polypeptide drugs, there are still many difficulties. Almost all the mucosal delivery of polypeptide drugs requires a strong stimulation of penetration enhancers.

Method used

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  • Method for preparing oral administered sustained-release peptide micro capsule
  • Method for preparing oral administered sustained-release peptide micro capsule
  • Method for preparing oral administered sustained-release peptide micro capsule

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0016] Specific implementation mode one: this implementation mode is realized in this way:

[0017] (a) Put the polypeptide drug particles in a 0.01-10M salt solution containing 0.01-100 mg / ml polyanion (pH value is between 1 and 6) for adsorption for 0.1-100 minutes;

[0018] (b) Centrifuge or filter to remove unadsorbed polyanions, and repeat washing several times with 0.01-10M salt solution (pH value between 1 and 6), each washing for 0.1-100 minutes;

[0019] (c) placing the prepared particles in a 0.01-10M salt solution (pH value between 1 and 6) containing 0.01-100 mg / ml polycation for adsorption for 0.1-100 minutes;

[0020] (d) Centrifuge or filter to remove unadsorbed polycations, and repeat washing with 0.01-10M salt solution (pH value between 1 and 6) several times, each time washing for 0.1-100 minutes;

[0021] (e) Steps (a) to (d) are repeated in sequence to obtain polypeptide drug microcapsules assembled with different layers of polymers.

[0022] In this embo...

specific Embodiment approach 2

[0028] Specific implementation mode two: this implementation mode is realized in this way:

[0029] (a) Put the insulin microparticles in a sodium polystyrene sulfonate solution containing 0.01-100 mg / ml (0.01-10 M inorganic salt in a 0.001-100 mM hydrochloric acid solution) for adsorption for 0.1-100 minutes;

[0030] (b) Centrifuge to remove unadsorbed sodium polystyrene sulfonate, repeat washing several times with 0.001-100mM hydrochloric acid solution containing 0.01-10M inorganic salts, and wash for 0.1-100 minutes each time;

[0031] (c) Place the prepared particles in polyallyl ammonium hydrochloride solution containing 0.01-100 mg / ml (0.001-100 mM hydrochloric acid solution containing 0.01-10 M inorganic salt) for adsorption for 0.1-100 minutes;

[0032] (d) Centrifuge to remove unadsorbed polyallyl ammonium hydrochloride, and repeat washing several times with 0.001-100 mM hydrochloric acid solution containing 0.01-10 M inorganic salt, each washing for 0.1-100 minutes;...

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Abstract

The invention relates to a method for using template nanometer self-assemble technique to prepare polypeptide oral microcapsule, which comprises: using polypeptide grain as template grain; using two biological compatible macromolecules with reversed charges as wall material; based on mutual attraction between different charges, combining the macromolecule materials from layer to layer, to form thin protective film on the surface of polypeptide grain, to obtain the polypeptide microcapsule. The invention is stable in acid medium, but releases polypeptide medicine in neutral medium, to keep the function of polypeptide grain in oral. And the polypeptide microcapsule can be dispersed into water or other liquid to form variable micro nanometer polypeptide oral liquid; or mixing the micrometer or sub-micron polypeptide microcapsule to form sheets, ejections, etc.

Description

Technical field: [0001] The invention belongs to the field of novel pharmaceutical preparations, and relates to a preparation method of oral polypeptide medicine slow-release microcapsules. Background technique: [0002] Compared with chemically synthesized drugs, peptide high-value biochemical drugs have the advantages of less side effects, less dosage, and better curative effect, and are generally welcomed by doctors and patients. With the development of genetic engineering technology, many polypeptide drugs such as insulin and interferon can be effectively developed through gene recombination technology, so they have broad development prospects. [0003] In today's society, the number of obese people is increasing, and due to people's lack of exercise and the aging trend of the population, the incidence of diabetes has risen sharply. Globally, diabetes has become the "third killer" that threatens human beings after cardiovascular and cerebrovascular diseases and tumors. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K38/16A61K38/28A61K47/30A61P3/10
Inventor 戴志飞岳秀丽邢雷
Owner HARBIN INST OF TECH
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