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A novel 'Tian Meng' soft capsule and preparation method thereof

A technology for soft capsules and hard capsules, applied in the directions of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of low active ingredients in soft capsules, poor patient compliance, and increased dosage, and reach the disintegration time limit. Short, fast absorption in the body, reasonable loading effect

Inactive Publication Date: 2006-12-13
江西欧氏药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key to the technology of preparing soft capsules is how to solve the problem of uniformity and stability of the contents. Due to the complexity of Chinese medicine extracts, in order to obtain products that meet quality standards, this patent uses conventional vegetable oil as a diluent, with oil-wax mixture and beeswax as aids. Suspension method, thus resulting in low active ingredients of each soft capsule and increased dosage. On the one hand, the patient’s compliance is poor, and on the other hand, the excessive dosage of excipients brings unforeseen adverse reactions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1, extract and prepare the active ingredient of sweet dream soft capsule

[0040] Prescription: Acanthopanax 177.59g, Polygonatum 222.01g, Silkworm Moth 44.39g

[0041] Mulberry 110.99g Codonopsis 133.20g Astragalus 133.20g

[0042] Amomum 17.75g Goji berry 133.20g Hawthorn 532.80g

[0043] Rehmannia glutinosa 88.81g Epimedium (made) 88.81g Chenpi 88.81g

[0044] Poria cocos 88.81g Nuxychia (manufactured) 4.43g Fa Pinellia 88.81g

[0045] Alisma 133.20g Yam 88.81g

[0046] The total weight of the prescription of the above seventeen medicinal materials is 2176g, add 10 times the amount of water to decoct twice, the first time is 1.5 hours, and the second time is 1 hour, the decoction is combined, filtered, the filtrate is concentrated to an appropriate amount, and ethanol is added to reduce the alcohol content. reach 65%, stand still, take the supernatant to reclaim ethanol, concentrate to thick paste, dry, and pulverize to obtain about 400g of medicinal p...

Embodiment 2

[0047] Embodiment two, preparation suspending agent oil-wax mixture

[0048] Take 200g of beeswax, 600g of hydrogenated coconut oil, and 200g of hydrogenated vegetable oil, heat to 80°C to melt to obtain an oil-wax mixture, stir well and let cool.

Embodiment 3

[0049] Embodiment three, preparation soft capsule material

[0050] Preparation of capsule material: Take 5000g of gelatin and 4500g of water, heat to 70°C, take 1750g of glycerin, 15g of methyl paraben, stir, vacuumize for 1 hour, mix with the above gelatin / water, keep it at 70°C overnight.

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PUM

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Abstract

The invention relates to a soft capsule and method of preparation, wherein the content comprises active constituents, Tween, Span or poloxamer-188 with right amount of vegetable oil and suspension aid agent by the weight ratio of 1:0.006-0.010.

Description

technical field [0001] The invention relates to a new dosage form of sweet dream hard capsule, a new sweet dream soft capsule and a preparation method thereof. Background technique [0002] Tianmeng Oral Liquid and Tianmeng Hard Capsules that are currently on the market are derived from the wolfberry pills in the famous ancient Chinese medical book "Miraculous Prescriptions", and have been modified and modified through years of clinical practice, as well as the flexible use of modern preparations. Successfully developed by learning new theories and new technologies. Practice has proved that the prescription is rigorous and treats both symptoms and root causes. The whole prescription cooperates with yin to seek yang, and yang to seek yin to achieve yin and yang secrets. Medicine for weakness. [0003] Tianmeng Hard Capsules are recorded in the Ministry of Health of the People's Republic of China Drug Standards Traditional Chinese Medicine Pre...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K9/48A61P25/20
Inventor 赵凯苑洪忠肖宝华
Owner 江西欧氏药业有限责任公司
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