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Composition of Chinese traditional medicine for curing cough and asthma, and preparation method

A composition and technology of traditional Chinese medicine, applied in the direction of drug combination, pharmaceutical formula, active ingredients of heterocyclic compounds, etc., can solve problems such as arrhythmia or sudden drop in blood pressure, accelerated development of osteoporosis, side effects, etc.

Active Publication Date: 2006-12-06
云南云河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patients who take these drugs for a long time are likely to develop dependence and cause serious side effects, for example: intravenous aminophylline can easily cause dizziness, palpitations, nausea, arrhythmia or sudden drop in blood pressure and other adverse reactions
Long-term use of glucocorticoids is likely to produce adverse reactions such as inhibiting the hypothalamus-pituitary-adrenaline axis, accelerating the development of osteoporosis, and affecting children's growth and development

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] [Example 1] Preparation of Coleus extract of the present invention

[0069] Coleus medicinal material is crushed and extracted three times with 95% ethanol or methanol. The amount of the three extracts is 5 times, 3 times, and 2 times the weight of the medicinal material respectively; the extraction time is 24 hours, 8 hours, and 8 hours respectively; Or heat reflux for 4 hours, 2 hours, or 2 hours. The solvent is recovered from the obtained extract to obtain an extract. For silica gel column chromatography, petroleum ether-acetone for gradient elution. The eluate is collected, the solvent is recovered, and then heated and concentrated at 60°C. The resulting concentrate contains isoforskolin ≥1.0%, which is the desired coleus extract.

Embodiment 2

[0070] [Example 2] Preparation of Coleus extract of the present invention

[0071] Example 1 was repeated, with the following differences: acetone was used for extraction three times, and the amount of acetone each time was 5, 3, and 2 times the weight of the medicinal material; the extract was chromatographed on silica gel or alumina and heated and concentrated at 65°C.

Embodiment 3

[0072] [Example 3] Preparation of Coleus extract of the present invention

[0073] Example 1 was repeated with the following differences: extraction with ethyl acetate was used three times, and the amount of ethyl acetate each time was 5, 3, and 2 times the weight of the medicinal material; the extract was treated with an adsorption resin column and heated and concentrated at 70°C.

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PUM

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Abstract

A Chinese medicine for treating cough, asthma, bronchal astha, bronchitis, etc is prepared from the extract of coleus forskohlin and bergeninum. Its preparing process is also disclosed.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition, and more specifically, the present invention relates to a pharmaceutical composition for treating asthma and cough diseases made with botanicals as main raw materials. At the same time, the present invention also relates to a method for preparing the pharmaceutical composition. Background technique [0002] Wheezing, coughing, and sputum are common symptoms of respiratory diseases, most of which are caused by infection or inflammation caused by antigens. The drugs currently used clinically to treat bronchial asthma or chronic bronchitis are correspondingly divided into several categories, such as anti-inflammatory, anti-allergic and bronchiectasis. Its pharmaceutical ingredients are mainly divided into β-adrenergic receptor agonists, theophyllines, anticholinergics, glucocorticoids, antihistamines and antileukotrienes, and cromolyn sodium. However, patients who take these d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P11/06A61P11/14A61P11/10A61K31/35
Inventor 刘剑张嘉硕陈植和许云龙金岐端
Owner 云南云河药业股份有限公司
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